| 木糖醇对糖尿病大鼠肾小管环氧化酶-2表达的影响 |
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| 引用本文： | 沈丽津,尹彦斌,苏悦,刘倩,于德民,孙丽荣. 木糖醇对糖尿病大鼠肾小管环氧化酶-2表达的影响[J]. 天津医药, 2010, 38(3) |
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| 作者姓名： | 沈丽津 尹彦斌 苏悦 刘倩 于德民 孙丽荣 |
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| 作者单位： | 1. 天津医科大学代谢病医院,300070
2. 天津市第三中心医院 |
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| 摘 要： | 目的:探讨不同剂量木糖醇对糖尿病大鼠肾小管环氧化酶-2(COX-2)表达的影响.方法:将大鼠随机分为正常对照组、糖尿病对照组、5%木糖醇组(低剂量组)、10%木糖醇组(中剂量组)和20%木糖醇组(高剂量组).第8周末,测定每组大鼠血清及尿液中尿酸、尿囊素和肌酐水平,取肾脏测定肾小管COX-2免疫组化表达情况.结果:(1)血尿酸、尿囊素水平在低、中剂量组高于糖尿病对照组,其中中剂量组升高差别有统计学意义(P＜0.05);高剂量组低于糖尿病对照组(P＞0.05).(2)尿尿酸水平在低、中剂量组尿尿酸低于糖尿病对照组,但差异无统计学意义(P＞0.05),低、中剂量尿尿囊素低于糖尿病对照组(P＜0.05);高剂量组尿尿酸、尿囊素高于糖尿病对照组(P＜0.05).(3)尿酸清除分数在低、中剂量组低于糖尿病对照组(P＜0.05);高剂量组高于糖尿病对照组(P＜0.05).(4)肾小管COX-2表达与糖尿病对照组相比,低、中剂最组呈高表达(P＜0.05),高剂量组则呈低表达(P＜0.05).结论:低、中剂量木糖醇致血尿酸水平升高,COX-2表达增强,加重肾小管的损伤.高剂量木糖醇可使糖尿病大鼠尿酸排泄增加,血尿酸水平降低,肾小管COX-2表达降低.
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| 关 键 词： | 木糖醇 糖尿病 尿酸 肾小管 环氧化酶2 大鼠,Wistar |
Effect of Xylitol on the COX-2 Expression of Renal Tubule in Diabetic Rats |
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| SHEN Lijin,YIN Yanbin,SU Yue,LIU Qian,YU Demin,SUN Lirong. Effect of Xylitol on the COX-2 Expression of Renal Tubule in Diabetic Rats[J]. Tianjin Medical Journal, 2010, 38(3) |
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| Authors: | SHEN Lijin YIN Yanbin SU Yue LIU Qian YU Demin SUN Lirong |
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| Affiliation: | SHEN Lijin,YIN Yanbin,SU Yue,LIU Qian,YU Demin,SUN Lirong Department of Diabetes , Gout,The Metabolic Disease Hospital of Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Objective:To observe the effect of xylitol on the cyclooxygenase (COX)-2 expression of renal tubule in diabetic rats. Methods: The Wistar rats were randomly divided into normal control group (group NC), diabetes control group(group DC), 5% xylitol-treated group (group 5%), 10% xylitol-treated group (group 10%) and 20% xylitol-treated group (group 20%). At the end of 8 weeks,the expression of COX-2 in kidney tissue, the level of serum uric acid , allantoin and creatinine were tested in rat groups. Results: T... |
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| Keywords: | xylitol diabetes mellitus uric acid kidney tubules cyclooxygenase 2 rats,Wistar |
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