Alterations in extracellular matrix components in transplant glomerulopathy |
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Authors: | Hyeon Joo Jeong Sun Hee Sung Soon Won Hong Jang Il Moon Soon Il Kim Yu Seun Kim Kiil Park |
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Affiliation: | (1) Department of Pathology, Yonsei University College of Medicine, Korea, KR;(2) Department of Pathology, Yongdong Severance Hospital, 146-92 Dogok-dong, Kangnam-Ku, Seoul, 135-270, Korea e-mail: jeong10@yumc.yonsei.ac.kr Tel.: +82-2-34973543, Fax: +82-2-34632103, KR;(3) Department of Pathology, Ewha Women’s University College of Medicine, Korea, KR;(4) Department of Surgery, Yonsei University College of Medicine, Korea, KR |
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Abstract: | The distribution pattern of extracellular matrix (ECM) components in transplant glomerulopathy was studied in relation to
light microscopic features, actin expression of mesangial cells, and intraglomerular inflammatory cells. Nine cases of mild
(group I) and nine cases of severe (group II) transplant glomerulopathy were stained with antisera against fibronectin (FN),
tenascin (TN), collagen types III and IV, smooth muscle actin, CD45RO, CD68, and Ki-67 antigen. The composition of ECM was
similar in the two groups. The expanded mesangium was diffusely stained by type-IV collagen, FN and TN, and focally and weakly
stained by type-III collagen and smooth muscle actin. Type-IV collagen was linearly stained along the capillary walls, imparting
a double-contour feature, whereas FN and TN showed granular staining along the capillary walls. CD68 positive cells were increased
in severe transplant glomerulopathy, but this increase was not related to ECM deposition. These findings suggest that increased
glomerular deposition of normal and abnormal ECM components participate in the evolution of transplant glomerulopathy.
Received: 5 October 1999 / Accepted: 17 January 2000 |
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Keywords: | Transplant glomerulopathy Extracellular matrix Actin Inflammatory cells |
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