Scaling-up of a batch whey fermentation by Kluyveromyces fragilis |
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Authors: | Mauro Moresi Michele Patete and Antonio Trunfio |
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Affiliation: | (1) I.M.T.A.F., University of Basilicata, Via Nazario Sauro 85, 85100 Potenza, Italy;(2) Rasa-Realtur SpA, Località Coppa del Fascione, 71043 Manfredonia (Foggia), Italy;(3) Present address: Colgate-Palmolive Italy, 00042 Anzio, Italy |
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Abstract: | Summary A whey fermentation by Kluyveromyces fragilis was scaled-up to a 1000-dm3 stirred fermentor, by varying the stirrer speed, the air-flow rate and the initial concentration of lactose. Its evolution was simulated by applying the same unstructured model (consisting of a microbial specific growth rate of pseudo-first order with respect to the COD concentration and constant biomass yield per unit COD removed) set up in previous experiments using 8- to 80-dm3 fermentors. Despite the great scale-up ratios, very different operating conditions, and geometric dissimilarity, a series of empirical regressions previously developed allowed approximate, but acceptable prediction of the stoichiometric and kinetic coefficients of the above mathematical model, thus confirming the capability of this model to provide a reliable basis for further scale-up of this fermentation process to a production scale. |
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