BIRC5基因在非小细胞肺癌中的表达及与免疫细胞浸润和预后的关系

目的:通过生物信息学方法分析杆状病毒凋亡抑制蛋白5(baculoviral inhibitor of apoptosis repeat-containing protein 5,BIRC5)基因在非小细胞肺癌(non-small cell lung cancer,NSCLC)与正常组织中的表达差异,并分析其与NSCLC...

BIRC5 gene expression in non-small cell lung cancer and its correlation with immune cells infiltration and prognosis

Objective:To analyze the differences between the expression of baculoviral inhibitor of apoptosis repeat-containing protein 5(BIRC5)in non-small cell lung cancer(NSCLC)and normal tissues using bioinformatics analysis,and to analyze its relationship with NSCLC prognosis and immune cells infiltration level.Methods:The GEPIA database was utilized to investigate the expression level of BIRC5 in NSCLC and normal lung tissue.The correlation between BIRC5 expression and immune cells infiltration level and immune cells infiltration-related gene markers in NSCLC was analyzed by Sperman's correlation test on TIMER database and GEPIA database.Finally,the relationship between the expression of BIRC5 and NSCLC prognosis was analyzed by Kaplan-Meier plotter.Results:BIRC5 expression level in NSCLC was increased compared with normal tissues(P<0.05).BIRC5 gene is significantly related to the infiltration level of various immune cells and their genetic markers in NSCLC immuno-microenvironment.Multivariate Cox regression analysis showed that low infiltration of B cells and high expression of BIRC5 were independent risk factors of poor prognosis in lung adenocarcinoma(P<0.05).Survival analysis showed that high expression of BIRC5 was significantly associated with poor prognosis in NSCLC(P<0.05).Conclusion:The expression of BIRC5 gene was increased in NSCLC,which affected the level of NSCLC immune cells infiltration and resulting in the imbalance of immune microenvironment,which in turn caused poor clinical prognosis.BIRC5 gene is expected to be a biological marker associated with NSCLC immune cells infiltration and prognosis.