缺血性脑卒中及其他神经退行性疾病对RNFL厚度的影响

视网膜和大脑具有相似的胚胎起源及解剖学和生理学特征,视网膜神经纤维层(RNFL)主要由视网膜神经节细胞的轴突在视神经结合之前组成,可以利用光学相干断层成像(OCT)在活体内进行观察和量化。RNFL变薄是正常衰老的一部分,也可见于缺血性脑卒中、阿尔兹海默病、帕金森病以及多发性硬化症等神经退行性病变。随着OCT等眼科影像技术的高度发展,RNFL厚在临床上广泛应用,为缺血性脑卒中及其他神经退行性疾病患者提供了视网膜神经节细胞丢失的临床数据。临床医师可以及早进行干预,延缓视网膜神经纤维层缺损的进展,进一步提高患者的生活质量。

Effects of ischemic stroke and other neurodegenerative diseases on RNFL thickness

The retina and the brain have similar embryonic origin and anatomical and physiological characteristics. The retinal nerve fiber layer(RNFL)is mainly composed of axons of retinal ganglion cells, which can be observed and quantified in vivo by optical coherence tomography(OCT). RNFL thinning is a part of normal aging, it can also be seen in neurodegenerative diseases such as ischemic stroke, Alzheimer's disease, Parkinson's disease,multiple sclerosis. With the rapid development of ophthalmic imaging techniques such as OCT, RNFL thickness is widely used in clinic,which provides clinical data of retinal ganglion cell loss in patients with ischemic stroke and other neurodegenerative diseases. Clinicians can intervene as soon as possible to delay the progress of retinal nerve fiber layer defect and further improve the quality of life of patients.