| 儿茶酚氧位甲基转移酶基因多态性与抑郁症症状表型的关联性研究 |
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| 引用本文： | 蔡理荣,张璐璐,郑洪波. 儿茶酚氧位甲基转移酶基因多态性与抑郁症症状表型的关联性研究[J]. 齐齐哈尔医学院学报, 2009, 30(2): 129-131 |
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| 作者姓名： | 蔡理荣 张璐璐 郑洪波 |
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| 作者单位： | 广东省佛山市顺德区伦教医院,528308;广东省广州市精神病医院,528308 |
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| 基金项目： | 广州市医药卫生科技项目 |
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| 摘 要： | 目的探讨中国汉族儿茶酚氧位甲基转移酶（COMT）基因多态性与抑郁症及症状表型的相关性。方法应用聚合酶链反应（PCR）及聚丙烯酰胺凝胶电泳（PAGE）方法,检测抑郁症患者（患者组）和健康志愿者（对照组）COMT基因多态性分布。采用24项汉密尔顿抑郁量表（HAMD24）评定患者组的症状表型。结果COMT等位基因与基因型频率在患者组和对照组内均有显著性差异（χ^2检验,P均〈0.01）,在两组间无显著性差异（χ^2检验,P均〉0.05）;患者组COMT等位基因、基因型在HAMD24认知障碍因子分上均有显著性差异（F检验,P均〈0.05）;患者组基因型A/A与认知障碍（r=-0.210,P=0.036）、绝望感（r=-0.331,P=0.001）均呈负相关;等位基因A与绝望感呈负相关（r=-0.220,P=0.028）;等位基因G与认知障碍（r=0.210,P=0.036）、绝望感（r=0.331,P=0.001）均呈正相关。结论提示COMT基因多态性与抑郁症症状表型可能相关。
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| 关 键 词： | 抑郁症 儿茶酚氧住甲基转移酶 基因多态性 表型 |
Association of catechol-O-methyltransferase gene polymorphism with depression and symptom phenotypes |
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| CAI Li-rong,et al.. Association of catechol-O-methyltransferase gene polymorphism with depression and symptom phenotypes[J]. Journal of Qiqihar Medical College, 2009, 30(2): 129-131 |
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| Authors: | CAI Li-rong et al. |
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| Affiliation: | Shunde Lunjiao Hospital;Foshan;Guangdong 528308 China |
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| Abstract: | Objective To explore the association among the depression,symptom phenotypes and polymorphism COMT in the Han Nationality.Methods The polymerase chain reaction(PCR)and polyacrylamide gel electrophoresis(PAGE) technique were used to detect COMT gene polymorphism in patients with depression(study group),and 100 healthy people were involved as controls(control group).The 24-item Hamilton Depression Scale(HAMD24) was used to evaluated symptom phenotypes of study group.Results Significant differences in COMT gen... |
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| Keywords: | Depression COMT Gene polymorphism Phenotype |
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