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Analyses of monoclonal antibodies reacting with porcine wCD6: Results from the Second International Swine CD workshop |
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| Authors: | M. D. Pescovitz, B. K. Book, B. Aasted, J. Dominguez, R. Bullido, I. Trebichavsky, B. Novikov, I. Valpotic, J. Nielsen, S. Arn, D. H. Sachs, J. K. Lunney, P. C. Boyd, J. Walker, R. Lee, N. Petrinec,A. Saalmü ller |
| Affiliation: | a Indiana University, Dept. of Surgery and Microbiology/Immunology, Indianapolis, IN 46202, USA b Royal Veterinary and Agricultural University, Frederiksberg C, Denmark c Centro de Investigaciones en Sanidad Animal, INIA, Valdeolmos, Madrid, Spain d Institute Microbiology, Prague, Czech Republic e All-Russian Research Institute of Veterinary Virology and Microbiology, Vlasimizskaya obl., Russian Federation f Department of Biology, Veterinary Faculty, University of Zagreb, Zagreb, Croatia g Danish Veterinary Institute for Virus Research, Lindholm, Kalvehave, Denmark h Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA i Immunology and Disease Resistance Laboratory, LPSI, ARS, USDA, Beltsville, MD, USA j Center for Animal Biotechnology, University of Melbourne, Victoria, Australia k Institute of Immunology, Zagreb, Croatia l Federal Research Center for Virus Diseases of Animals, Tübingen, Germany |
| Abstract: | Among the 57 monoclonal antibodies analyzed within the T-cell group of the Second International Swine CD Workshop, one mAb fell within cluster T14a that included the CD6 standard a38b2 (No. 175). The new mAb MIL8 (No. 082) and a38b2 both precipitated from activated T-cells a 150 kDa monomeric protein. Staining patterns on the various cell types were similar. There was no inhibition of binding of either mAb to peripheral blood T-cells with the opposite mAb. The new mAb, MIL8, reacts with a separate epitope on porcine wCD6. |
| Keywords: | Monoclonal antibodies T-cells porcine wCD6 |
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