草酸铂为主联合化疗方案治疗晚期大肠癌的临床观察

目的 观察草酸铂(OXA)联合醛氢叶酸(CF)，5-氟脲嘧啶(5-Fu)治疗晚期大肠癌的近期疗效及毒副反应。方法 OXA130mg／m^2，iv drip dl；CF100mg，iv dl-5；5-Fu375mg／m^2，iv dl-5。以上方案每21天为一周期，至少完成二周期。结果 CR1例，PR8例，SD9例，PD7例。总有效率36．0％，主要毒副反应为恶心呕吐和血白细胞减少，外周神经感觉异常。结论 草酸铂为主联合化疗方案治疗晚期大肠癌疗效较好，毒副反应可耐受，值得临床推广应用。

Preliminary clinical observation with oxaliplatin based chemotherapy regimen in the treatment of advanced colorectal cancer

Objective To observe the therapeutic effects and toxicity of Oxaliplatin(OXA) and 5-Fluorouracil(5-Fu) based chemotherapy regimen in the treatment of advanced colorectal cancer.Methods Twenty five cases of advanced colorectal cancer were treated with the regimen:OXA 130mg/m 2,iv gtt dl;CF 100mg,iv gtt dl-5;5-Fu 375mg/m 2,iv gtt dl-5.The cycle was 21 days.The effect was evaluded after 2cycles.Results Complete response was achieved in 1 case, partial response in 8 cases, stablieness in 9 cases and progression in 7 cases.The overall response rate was 36.0%.The main toxicity was nausea,vomiting,leucopenia and peripheral sensitive neutropathy. Conclusion Advanced colorectal cancer patients treated by Oxaliplatin(OXA)and 5-Fluorcuracil(5-Fu) based chemotherapy regimen shows a better therapeutic effect and toxic side effects are tolerant, which is worthy of further clinical trial.