| 血、尿中氯硝西泮及其代谢物7-氨基氯硝西泮的GC-ECD法检测 |
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| 引用本文： | 邢丽梅,谭家镒,李发美,姚丽娟,姜兆林,陈玉芬,刘俊.血、尿中氯硝西泮及其代谢物7-氨基氯硝西泮的GC-ECD法检测[J].分析试验室,2003,22(1):28-31. |
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| 作者姓名： | 邢丽梅 谭家镒 李发美 姚丽娟 姜兆林 陈玉芬 刘俊 |
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| 作者单位： | 1. 中国刑警学院法医系,沈阳,110035
2. 沈阳药科大学,沈阳,110015 |
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| 摘 要： | 报道了血、尿中氯硝西泮及其代谢物7－氨基氯硝西泮的GC－ECD检测方法。苯－异戊醇碱性条件下（pH10.8）液－液萃取，灵敏度较高，氯硝西泮和7－氨基氯硝西泮的检测限（LOD）分别为3．2ng/mL及1．7ng/mL。线性范围5－300ng/mL，RSD5．3％。
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| 关 键 词： | 氯硝西泮 7－氨基氯硝西泮 气相色谱 血浆 尿 |
| 文章编号： | 1000-0720(2003)01-0028-04 |
Determination of clonazepam and 7-aminoclonazeparn by GC-ECD in human plasma and urinesamples |
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| XING Li-mei,TAN Jia-yi,YAO Li-juan,CHEN Yu-fen,LIU Jun.Determination of clonazepam and 7-aminoclonazeparn by GC-ECD in human plasma and urinesamples[J].Chinese Journal of Analysis Laboratory,2003,22(1):28-31. |
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| Authors: | XING Li-mei TAN Jia-yi YAO Li-juan CHEN Yu-fen LIU Jun |
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| Abstract: | A GC-ECD procedure was developed for the determination of clonazepam and 7-aminoclonazepam .Drugs were extracted from human plasma and urine samples with benzene-isoamyl alcohol(98.5+1.5) at pH 10.8 and then determined by GC-ECD. The detection limits were 3.2 ng/mL and 1.7 ng/mL for clonazepam and 7-aminoclonazepam, respectively. |
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| Keywords: | clonazepam 7-aminoclonazepam plasma urine GC-ECD |
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