Prevention of irinotecan associated diarrhea by intestinal alkalization. A pilot study in gastrointestinal cancer patients |
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Authors: | Vicente Valentí Moreno Joan Brunet Vidal Hermini Manzano Alemany Antonia Saulud Salvia Montserrat Llobera Serentill Inés Cabezas Montero Sonia Servitja Tormo Eugenia Sopena Bert Josep Gumà Padró |
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Affiliation: | (1) Catalan Instiute of Oncology, Hospital Dr Josep Trueta, Gironal, Spain;(2) Medical Oncology Department, Hospital Son Dureta, Palma de Mallorca, Spain;(3) Medical Oncology Department, Hospital Arnau de Vilanova, Leloida, Spain;(4) Medical Oncology Department, Hospital Verge de la Cinta, Tortosa, Spain;(5) Medicine Department, Universitat Rovira i Virgilia, Reus, Spain;(6) Medical Oncology Department, Hospital Universitari de Sant Joan, C/Sant Joan, s/n 43201 Reus, Tarragona, Spain |
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Abstract: | Aim and background Intestinal alkalization could prevent irinotecan associated diarrhea modulating some chemical equilibria between irinotecan metabolites. The aim of this study was to evaluate the efficacy of this procedure in advanced gastrointestinal cancer patients (GICP). Materials and method In this prospective study advanced GICP, receiving irinotecan based chemotherapy regimens, were well trained, to add sodium bicarbonate to the water intake in order to accomplish intestinal alkalization. Results A total of twenty four advanced GICP were enrolled. Grade III–IV diarrhea has been observed in four patients (16%), some of whom had several risk factors for diarrhea. Only one out of seventeen colorectal cancer patients, receiving the irinotecan combination as first line therapy, had grade III–IV diarrhea. No side effects of the procedure have been appreciated. Conclusions Intestinal alkalization may be effective as a preventive treatment for irinotecan associated diarrhea in chemotherapy regimens used in GICP. This procedure deserves further investigation. An erratum to this article is available at . |
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Keywords: | irinolecan intestinal alkalization diarrhea gastrointestinal cancer |
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