| DNA修复基因XRCC 1研究进展 |
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| 引用本文： | 张文娟,吴逸明,吴拥军. DNA修复基因XRCC 1研究进展[J]. 医学分子生物学杂志, 2004, 1(4): 239-241 |
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| 作者姓名： | 张文娟 吴逸明 吴拥军 |
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| 作者单位： | 郑州大学公共卫生学院职业卫生与毒理学教研室,郑州市,450052;郑州大学公共卫生学院职业卫生与毒理学教研室,郑州市,450052;郑州大学公共卫生学院职业卫生与毒理学教研室,郑州市,450052 |
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| 基金项目： | 国家教育部"211工程"重点学科资助项目 |
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| 摘 要： | X线修复交叉互补基因1(XRCC 1)是一种重要的DNA修复基因,参与DNA单链断裂和碱基损伤修复,位于人染色体19q13.2,编码区单核苷酸多态位点导致相应的氨基酸改变.对其生物学特性、结构功能、基因多态与疾病易感性等方面的研究,可深入理解XRCC 1基因多态与环境交互作用对个体易感性的重要影响,其可能是某些疾病如癌症发生中潜在的易感标志物,对特定亚人群的筛检、预防和指导临床用药有深远意义.
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| 关 键 词： | XRCC 1 BRCT结构域 基因多态性 易感性 |
| 修稿时间： | 2004-02-25 |
Advances in DNA Repair Gene XRCC 1 |
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| ZHANG Wenjuan,WU Yiming,WU Yongjun. Advances in DNA Repair Gene XRCC 1[J]. Journal of Medical Molecular Biology, 2004, 1(4): 239-241 |
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| Authors: | ZHANG Wenjuan WU Yiming WU Yongjun |
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| Affiliation: | ZHANG Wenjuan,WU Yiming,WU Yongjun Department of Occupational Health and Toxicology,College of Public Health,Zhengzhou University,Zhengzhou,450052,China |
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| Abstract: | The X-ray repair cross-complementing 1 ( XRCC 1 ) plays a critical role in repair of single-strand breaks and base damage, and is located on human chromosome 19q13.2. In encoding area, single nucleotide polymorphism results in the corresponding change of amino acid. The article reviews the biological features, structure and function, gene polymorphism and diseases susceptibility of XRCC 1. The review will help us gain insight into how the interaction between gene polymorphisms and environment influence the susceptibility of individuals. XRCC 1 gene may be a potential marker for susceptibility to some diseases, such as cancer and is important in the screening, prevention and drug treatement of disease in specific populations. |
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| Keywords: | XRCC 1 BRCT domain gene polymorphism susceptibility |
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