阿尔茨海默病与血管性痴呆患者雌二醇变化的相关性研究

目的探讨阿尔茨海默病与血管性痴呆患者雌二醇变化的相关性。方法对41例阿尔茨海默病患者与31例血管性痴呆患者的血清雌二醇水平进行测定分析。结果阿尔茨海默病与血管性痴呆患者雌二醇水平均有所下降，但女性较男性下降更为显著（t=4．963，5．622，P〈0．01）；阿尔茨海默病与血管性痴呆患者同性别间雌二醇水平无显著性差异（P〉0．05）。结论阿尔茨海默病与血管性痴呆患者雌二醇水平均有所下降，女性患者更为显著，雌二醇水平下降可能是阿尔茨海默病和血管性痴呆的危险因素之一。

Estradiol changes in Alzheimer''s disease and vascular dementia

Objective To explore the correelation between estradiol（E2） changes in Alzheimer＇s disease（AD） and vascular dementias（VD）. Mehtods Levels of serum estradiol were measured and analysed in 41 AD patients and 31 VD ones. Results The E2 levels of both the AD and VD patients low.ered to some extent, those of the female ones did more significantly than the male（P〈0.01）; there was no significant sex difference in E2 level of both the AD and VD patients（P〉0.05）. Conclusion The E2 levels of both the AD and VD patients lower to some extent and those of the female ones do more significantly,and the decrease of E2 levels may be one of risk factors of Alzheimer s disease and vaseular dementias.