| 白介素6在2型糖尿病大鼠胰岛素抵抗中的作用 |
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| 引用本文： | 陈雨,郑少雄,郝杰,孟春梅. 白介素6在2型糖尿病大鼠胰岛素抵抗中的作用[J]. 中国临床医学, 2011, 18(1): 32-34 |
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| 作者姓名： | 陈雨 郑少雄 郝杰 孟春梅 |
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| 作者单位： | 天津医科大学第二医院内分泌科,天津,300211 |
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| 基金项目： | 天津市卫生局科技基金计划项目 |
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| 摘 要： | 目的：观察白介素6（IL-6）抗原及IL-6抗体对2型糖尿病（T2DM）大鼠的影响,探讨IL-6等炎症因子对糖尿病胰岛素抵抗的作用。方法：36只SD T2DM大鼠,随机分为4组：糖尿病IL-6抗原组（A组）,糖尿病IL-6抗体组（B组）,糖尿病对照组（C组）,健康对照组（N组）。测定血糖、血清胰岛素、血脂、血游离脂肪酸和肝脏胰岛素受体。结果：脂肪乳灌胃（高糖高脂饮食）7周加小剂量1次尾静脉注射链脲佐菌素（STZ）可以成功诱导SD大鼠的T2DM模型,糖尿病组较正常对照组出现明显的高胰岛素血症、胰岛素抵抗、胰岛素敏感性降低和高脂血症;IL-6抗体干预可以降低T2DM大鼠的胰岛素水平,减轻其胰岛素抵抗。结论：IL-6抗体能够改善T2DM大鼠的胰岛素抵抗状态。
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| 关 键 词： | 2型糖尿病 白细胞介素6 胰岛素抵抗 胰岛素受体 白介素6抗体 |
The Role of Interleukin-6 on Insulin Resistant in Type 2 Diabetes Mellitus Rats |
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| CHEN Yu,ZHENG Shaoxiong,HAO Jie,MEN Chunmei. The Role of Interleukin-6 on Insulin Resistant in Type 2 Diabetes Mellitus Rats[J]. Chinese Journal Of Clinical Medicine, 2011, 18(1): 32-34 |
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| Authors: | CHEN Yu ZHENG Shaoxiong HAO Jie MEN Chunmei |
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| Affiliation: | CHEN Yu ZHENG Shaoxiong HAO Jie MEN Chunmei Department of Endocrinology,the Second Hospital of Tianjin University,Tianjin 300211,China |
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| Abstract: | Objective:To observe the influence of interleukin-6(IL-6) antigen and IL-6 antibody on type 2 diabetes mellitus rats,and to study the important role of IL-6 and other inflammation factors in the pathogenesis of diabetes.Methods: A total of 36 the type 2 diabetes mellitus SD rats were divided into four groups randomly:the diabetes mellitus IL-6 antigen group(Group A),diabetes mellitus IL-6 antibody group(Group B),diabetes mellitus control group(Group C),and normal control group(Group N).The serum insulin,lip... |
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| Keywords: | Type 2 diabetes mellitus Interleukin-6(IL-6) Insulin resistant Insulin receptor IL-6 antibody |
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