| 桂枝的引药作用机制及其对环丙沙星在小鼠体内分布的影响 |
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| 引用本文： | 李荣生,朱玲,丁建美,王吉,王振兴,徐晓玉,付志锋.桂枝的引药作用机制及其对环丙沙星在小鼠体内分布的影响[J].中国科学:化学,2011(5):856-862. |
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| 作者姓名： | 李荣生 朱玲 丁建美 王吉 王振兴 徐晓玉 付志锋 |
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| 作者单位： | 发光与实时分析教育部重点实验室西南大学药学院; |
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| 基金项目： | 国家自然科学基金(21035005); 西南大学本科生科技创新基金项目(0929001)资助 |
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| 摘 要： | 研究了桂枝和桂皮醛对环丙沙星在小鼠体内分布的影响,并基于此探讨了桂枝作为引药使用的作用机制.实验中将小鼠分为三组,分别灌胃生理盐水、桂枝(50gkg-1)和桂皮醛(0.25mLkg-1),然后对三组小鼠尾静脉注射环丙沙星(20mgkg-1),并以荧光法测定不同时间点小鼠体内各组织中环丙沙星的浓度.结果显示桂枝、桂皮醛均促进了环丙沙星在四肢的分布,桂枝与桂皮醛组相对于生理盐水组可将环丙沙星在四肢的含量提高约40%~200%,证实了桂枝引药到达肢节的作用.桂枝与桂皮醛组对环丙沙星分布情况的影响没有显著性差异,说明桂皮醛很可能是发挥桂枝引药作用的主要物质.
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| 关 键 词： | 桂枝 桂皮醛 引药 环丙沙星 药物分布 荧光分光光度法 |
The drug-guide mechanism of Guizhi and its effect on the distribution of ciprofloxacin in mice |
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| LI RongSheng,ZHU Ling,DING JianMei,WANG Ji,WANG ZhenXing,XU XiaoYu & FU ZhiFeng Key Laboratory on Luminescence , Real-Time Analysis,Ministry of Education,College of Pharmaceutical Sciences,Southwest University,Chongqing ,China.The drug-guide mechanism of Guizhi and its effect on the distribution of ciprofloxacin in mice[J].Scientia Sinica Chimica,2011(5):856-862. |
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| Authors: | LI RongSheng ZHU Ling DING JianMei WANG Ji WANG ZhenXing XU XiaoYu & FU ZhiFeng Key Laboratory on Luminescence Real-Time Analysis Ministry of Education College of Pharmaceutical Sciences Southwest University Chongqing China |
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| Affiliation: | LI RongSheng,ZHU Ling,DING JianMei,WANG Ji,WANG ZhenXing,XU XiaoYu & FU ZhiFeng Key Laboratory on Luminescence and Real-Time Analysis,Ministry of Education,College of Pharmaceutical Sciences,Southwest University,Chongqing 400716,China |
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| Abstract: | The drug-guide mechanism of Guizhi and its effect on the distribution of ciprofloxacin in mice were investigated in detail. Three groups of mice were administrated with physiological saline, Guizhi (50 g kg?1) and cinnamaldehyde (0.25 mL kg?1), respectively. Then ciprofloxacin was injected into tail intravenous of the mice. Afterward the concentrations of ciprofloxacin in the mice various tissues were determined by fluorospectrophotometry after different time. The results showed that Guizhi and cinnamaldehy... |
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| Keywords: | Guizhi cinnamaldehyde drug-guide ciprofloxacin drug distribution fluorospectrophotometry |
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