| NADPH氧化酶家族在心血管疾病中作用的研究进展 |
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| 引用本文： | 曹静,刘昭娅,胥茜,石瑞正,张国刚. NADPH氧化酶家族在心血管疾病中作用的研究进展[J]. 中南大学学报(医学版), 2000, 44(11): 1258-1267. DOI: 10.11817/j.issn.1672-7347.2019.180394 |
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| 作者姓名： | 曹静 刘昭娅 胥茜 石瑞正 张国刚 |
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| 作者单位： | 中南大学湘雅医院心血管内科，长沙 410008 |
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| 基金项目： | 国家重点基础研究发展计划(2014CB542402)；中南大学中央高校基本科研业务费专项资金资助(2018zzts896)。 |
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| 摘 要： | 烟酰胺腺嘌呤二核苷酸磷酸氧化酶是心血管系统中活性氧(reactive oxygen species，ROS)的主要来源，它包括7种亚型并分别表达在不同的心血管细胞及其细胞器中，参与调节细胞增殖、迁移、分化、凋亡、衰老和炎症反应等多种活动，其衍生的ROS参与高血压、动脉粥样硬化、糖尿病血管病变、心肌梗死后心室重构等多种心血管疾病的病理过程。
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| 关 键 词： | 活性氧 烟酰胺腺嘌呤二核苷酸磷酸氧化酶 结构 心血管疾病 |
Research progress in NADPH oxidase family in cardiovascular diseases |
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| CAO Jing,LIU Zhaoya,XU Qian,SHI Ruizheng,ZHANG Guogang. Research progress in NADPH oxidase family in cardiovascular diseases[J]. Journal of Central South University. Medical sciences, 2000, 44(11): 1258-1267. DOI: 10.11817/j.issn.1672-7347.2019.180394 |
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| Authors: | CAO Jing LIU Zhaoya XU Qian SHI Ruizheng ZHANG Guogang |
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| Affiliation: | Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China |
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| Abstract: | Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a major source of reactiveoxygen species (ROS) in the cardiovascular system. Th e family of NOX includes seven isoforms,and expressed in different cardiovascular cell types and cell compartments, modulating multiplefunctions, such as cell proliferation, migration, differentiation, apoptosis, senescence, andinflammatory responses. The NOX-derived ROS are involved in many processes associated withcardiovascular diseases, such as hypertension, atherosclerosis, diabetic vascular disease, ventricularremodeling aft er myocardial infarction, and so on. |
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| Keywords: | reactive oxygen species nicotinamide adenine dinucleotide phosphate oxidase structure cardiovascular diseases |
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