冠心病伴下肢外周动脉病住院患者患病率及用药状况分析

目的 了解我国冠心病住院患者下肢外周动脉病（peripheral arterial disease，PAD）的患病率及用药状况。方法 连续入选上海第十人民医院等32家医院的冠心病住院患者1228例为研究对象；测量踝臂指数（ankle-brachial index，ABI）并收集用药情况；ABI〈0．9诊断为PAD。结果 冠心病患者的PAD患病率为32．4％；PAD患者中67．6％使用他汀类药物，70．1％使用ACEI类药物，87．4％使用抗血小板药物，62．8％的PAD患者同时使用他汀类和抗血小板药物；多元分析PAD患者使用利尿剂的OR及95％CI为1．719（1．252～2．539），其他用药情况对PAD没有显示统计学差别。结论 冠心病患者常伴有下肢外周动脉病，临床上未引起对PAD的足够重视，应在治疗冠心病的同时给予PAD正规积极的治疗。

Prevalence Rate and Medication of Peripheral Arterial Disease in Hospitalized Patients with Coronary Heart Disease

Objective To study the prevalence and the medication of peripheral arterial disease(PAD) in Chinese hospitalized patients with coronary heart disease(CHD).Methods The medication of PAD was investigated in 1 228 Chinese hospitalized patients with CHD.PAD was diagnosed when the ankle-brachial index was<0.9,patients with an ankle-brachial index of >1.4 were excluded because of false negative rate.Potential confounding variables were adjusted in multivariate Logistic analysis.All data were performed with SPSS version 12.0 software.Results The prevalence of PAD in hospitalized CHD patients was 32.4%.Statin,angiotensin-converting enzyme-inhibitors and antiplatelet agents were used in 67.6%,70.1% and 87.4% PAD patients,respectively.Statin and antiplatelet agents were used in 62.8% PAD patients,synchronously.The multivariate-adjusted odds ratio for PAD with diuretic treatment was 1.719(95% confidence interval:1.252-2.539).Conclusion CHD often coexists with PAD,and aggressive medication is required in PAD patients.