| 无催化剂合成吡咯螺环氧化吲哚 |
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| 引用本文： | 景德红,刘雄伟,黄璇,郭丰敏,周英,刘雄利,余章彪. 无催化剂合成吡咯螺环氧化吲哚[J]. 遵义医学院学报, 2014, 0(4): 442-444 |
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| 作者姓名： | 景德红 刘雄伟 黄璇 郭丰敏 周英 刘雄利 余章彪 |
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| 作者单位： | 贵州大学药学院暨贵州省中药民族药创制工程中心,贵州贵阳550025 |
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| 基金项目： | 国家自然科学基金资助项目（NO：21302024）;贵州省中药现代化科技产业研究开发专项项目（NO：黔科合ZY字[2013]3010）;教育部“新世纪人才支持计划（NO：教技函[2011]95）. |
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| 摘 要： | 目的 为了获得具有潜在生物活性的吡咯螺环氧化吲哚类化合物.方法 以N-甲氧基羰基-3-芳环烯基氧化吲哚作为起始原料,通过与多聚甲醛和肌胺酸原位生成的1,3-偶极子的[3＋2]环加成反应,合成吡咯螺环氧化吲哚类化合物.结果 设计合成了7个未见文献报道的吡咯螺环氧化吲哚类化合物,其结构经过1H NMR,13CNMR和HRMS等技术确定.结论 吡咯螺环氧化吲哚类化合物合成产率在58％～67％.
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| 关 键 词： | 吡咯螺环氧化吲哚 环加成反应 偶极子 |
An efficient synthesis of pyrrolidinylspirooxindoles under catalyst-free conditions |
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| Jing Dehong,Liu Xiongwei,Huang Xuan,Guo Fengmin,Zhou Ying,Liu Xiongli,Yu Zhangbiao. An efficient synthesis of pyrrolidinylspirooxindoles under catalyst-free conditions[J]. Acta Academiae Medicine Zunyi, 2014, 0(4): 442-444 |
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| Authors: | Jing Dehong Liu Xiongwei Huang Xuan Guo Fengmin Zhou Ying Liu Xiongli Yu Zhangbiao |
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| Affiliation: | ( Guizhou Engineering Center for Innovative Traditional Chinese Medicine and Ethnic Medicine, College of Pharmacy, Guizhou University, Guiyang Guizhou 550025, China) |
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| Abstract: | Objective To obtain novel pyrrolidinylspirooxindoles with potential biological activity. Methods The pyrrolidinylspirooxindoles were synthesized viaa 1,3 -dipolar cycloaddition reaction of （E） -N- MeOCO -3 - alkylidene -indolin -2（3H）ones with azomethineylides in toluene at 80 ℃. Results The seven unreported 3 - substituted quaternary hydroxyoxindoles were synthesized, All their structures were characterized by 1H NMR, 13 C NMR and HRMS. Conclusion The seven unreported 3 - substituted quaternary hydroxyoxindoles were synthesized efficiently with 58% - 67% yields. |
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| Keywords: | pyrrolidinylspirooxindoles cycloaddition reaction azomethineylides |
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