| 酮康唑微囊的体外溶出度研究 |
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| 引用本文： | 尚北城,简晓娜,李桂乔,唐斌,张云玲. 酮康唑微囊的体外溶出度研究[J]. 华西药学杂志, 2003, 18(4): 273-274 |
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| 作者姓名： | 尚北城 简晓娜 李桂乔 唐斌 张云玲 |
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| 作者单位： | 1. 成都军区昆明总医院,云南,昆明,650032
2. 重庆大新药业开发研究处,重庆,400700 |
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| 摘 要： | 目的 研究酮康唑微囊的体外溶出特点。方法 按中国药典所载转蓝法进行体外溶出度测定。结果 酮康唑微囊在人工胃液中90min内可达到最大溶出，其最高累积溶出百分率接近90％，其溶出行为符合Weibull概率函数分布，相关参数为：药物溶出50％的t1/2=25min，特征数td=42min，形态参数m=0．6min。结论 酮康唑微囊在人工胃液中溶出较理想。
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| 关 键 词： | 酮康唑微囊 体外溶出度 人工胃液 人工肠液 |
| 文章编号： | 1006-0103(2003)04-0273-02 |
| 修稿时间： | 2003-02-01 |
The dissolution behavior of Ketoconazole microcapsules in vitro |
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| SHANG Bei-cheng ,JIAN Xiao-na ,LI Gui-qiao ,TANG Bin ,ZHANG Yun-ling .Kunming General Hospital of Chengdu Military Region,Kunming ,China,.Resarck and Developing. The dissolution behavior of Ketoconazole microcapsules in vitro[J]. West China Journal of Pharmaceutical Sciences, 2003, 18(4): 273-274 |
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| Authors: | SHANG Bei-cheng JIAN Xiao-na LI Gui-qiao TANG Bin ZHANG Yun-ling .Kunming General Hospital of Chengdu Military Region Kunming China .Resarck Developing |
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| Affiliation: | SHANG Bei-cheng 1,JIAN Xiao-na 2,LI Gui-qiao 1,TANG Bin 1,ZHANG Yun-ling 1 1.Kunming General Hospital of Chengdu Military Region,Kunming 650032,China,2.Resarck and Developing Department of Chongqing Daxin Parmaceutical Co.,Ltd,Chongqing 400700,China |
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| Abstract: | OBJECTIVE To prepare Ketoconazole microcapsules and to study on its dissolution behavior.METHODS According to Chinese Pharmacopoeia(2000 edition), the rotating basket method was employed.RESULTS The kinetics of Ketoconazole microcapsules in the simulated gastric fluid obeyed the Weibull Distribution.Approximate 90% Ketoconazole was released from microcapsules within 90 min, The parameters were t 1/2=25 min, t d=42 min and m=0.6 min.While the Ketoconazole powder released more than 95% Ketoconazole within 10 min in the same solvent.CONCLUSION The releasing of Ketoconazole from the microcapsules is ideal and showed sustained-release character compared with Ketoconazole powder. |
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| Keywords: | Ketoconazole Microcapsule Dissolution |
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