幽门螺杆菌与糖尿病视网膜病变关系的研究

目的: 分析老年人群幽门螺杆菌感染与2型糖尿病视网膜病变（DR）的关系。方法: 随机选择老年2型糖尿病患者和健康对照者各300例，均接受幽门螺杆菌感染检测，糖尿病患者接受眼科DR检查。采用多因素logistic回归分析法，评价幽门螺杆菌感染与DR发生的相关性。结果: 与健康对照组相比，糖尿病患者同时发生幽门螺杆菌感染的可能性显著增加（OR: 1.57，95%CI: 1.09~2.25，P＜0.001）。在糖尿病患者中，205例患者合并DR，95例患者未合并DR。与未合并DR的患者相比，DR患者同时发生幽门螺杆菌感染的可能性亦显著增加（OR: 5.01，95%CI: 2.77~9.05，P＜0.001）。结论: 老年人群幽门螺杆菌感染与DR发生之间存在显著的相关性。

Association between helicobacter pylori infection and diabetic retinopathy.

Objective : To explore the association between helicobacter pylori infection and diabetic retinopathy in elderly patients with type 2 diabetes mellitus. Methods: A total of 300 elderly patients with type 2 diabetes mellitus and 300 healthy controls were randomly selected. Helicobacter pylori test and diabetic retinopathy test were conducted. Association between helicobacter pylori infection and diabetic retinopathy was determined using multifactorial logistic regression analysis. Results: Compared with the healthy controls, helicobacter pylori infection was related with diabetic retinopathy in elderly patients with type 2 diabetes mellitus (OR: 1.57, 95%CI: 1.09~2.25, P＜0.001. Patients were divided into diabetic retinopathy group (n = 205) and non-diabetic retinopathy group (n = 95). The study revealed that helicobacter pylori infection was also associated with diabetic retinopathy (OR: 5.01，95%CI: 2.77~9.05，P＜0.001). Conclusion:Helicobacter pylori infection might be associated with diabetic retinopathy in elderly patients with type 2 diabetes mellitus.