| 大鼠前脑结构FOS蛋白表达与惊厥类型的关系 |
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| 引用本文： | 傅玉,赵丛海,王金兰,房向阳,田宇. 大鼠前脑结构FOS蛋白表达与惊厥类型的关系[J]. 吉林大学学报(医学版), 2003, 29(4): 433-435 |
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| 作者姓名： | 傅玉 赵丛海 王金兰 房向阳 田宇 |
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| 作者单位： | 1. 吉林大学中日联谊医院神经外科,吉林,长春,130031
2. 吉林大学中日联谊医院麻醉科 |
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| 基金项目： | 卫生部科研项目;98-1-205; |
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| 摘 要： | 目的 :探讨部分性癫痫和全身性癫痫发作的病理生理机制。方法 :建立局限性、全身性惊厥动物模型。采用免疫组织化学染色法观察惊厥组大鼠前脑结构内 FOS蛋白表达量及分布状况。结果 :无惊厥对照组大鼠仅于皮层偶见 FOS阳性细胞 ,局限性惊厥组大鼠皮层、尾状核、杏仁核和丘脑见大量 FOS阳性细胞表达 ,全身性惊厥组大鼠海马、皮层和丘脑见 FOS阳性细胞大量表达。结论 :局限性惊厥是由整个皮层高度兴奋机制实现 ;全身性惊厥泛化部位为齿状回 -海马 ,皮层的兴奋是继发于海马结构。全身性惊厥与局限性惊厥是两种类型的惊厥 ,不是连续过程的不同阶段
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| 关 键 词： | 惊厥 原癌基因蛋白质c-fos类 前脑结构 |
| 文章编号： | 1671-587X(2003)04-0433-03 |
| 修稿时间： | 2002-08-20 |
Relationship Between FOS Protein Expression in Rat Forebrain Structures and Types of Seizure |
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| FU Yu ,ZHAO Cong hai ,WANG Jin lan ,FANG Xiang yang ,TIAN Yu. Relationship Between FOS Protein Expression in Rat Forebrain Structures and Types of Seizure[J]. Journal of Jilin University: Med Ed, 2003, 29(4): 433-435 |
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| Authors: | FU Yu ZHAO Cong hai WANG Jin lan FANG Xiang yang TIAN Yu |
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| Affiliation: | FU Yu 1,ZHAO Cong hai 1,WANG Jin lan 2,FANG Xiang yang 1,TIAN Yu 1 |
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| Abstract: | Objective: To explore the patho physiological mechanism of generalized seizures and partial seizures. Methods: Generalized and partial seizures models were set. Immunohistochemistry was used to examine the quantity and distribution of FOS expression in rat forebrain structures. Results: FOS positire neurons were seen incidentally in cortical in control group rats without seizure. FOS positire neurons were seen in different level in generalized seizures and partial seizures group. Conclusion: Generalized seizure is a different type from partial seizure, but not a progression from the latter. |
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| Keywords: | Convulsions Proto oncogene proteins c fos Forebrain structures |
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