| 连续观察兔油酸ARDS模型稳定性及血L-1、IL-8近期变化 |
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| 引用本文： | 李英卓张志培范崇熙汪健倪云峰邓迎春杨菁李小飞 程庆书. 连续观察兔油酸ARDS模型稳定性及血L-1、IL-8近期变化[J]. 现代生物医学进展, 2011, 11(4): 637-641 |
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| 作者姓名： | 李英卓张志培范崇熙汪健倪云峰邓迎春杨菁李小飞 程庆书 |
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| 作者单位： | 第四军医大学唐都医院胸外科,陕西,西安,710038 |
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| 基金项目： | 全军医药卫生科研项目(2008080202) |
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| 摘 要： | 目的:探讨油酸(OA)构建兔急性呼吸窘迫综合征(ARDS)模型3天内的稳定性及血浆炎症因子IL-1、IL-8含量变化的意义。方法:健康新西兰大耳白兔30只随机分为5组,每组6只,实验组(n=24)耳缘静脉注射油酸(0.1mL/kg)建立ARDS模型,对照组(n=6)注射等量生理盐水。分别检测对照组6h和实验组6h、24h、48h、72h(n=6)动脉血PH值、PaO2、PaO2/FiO2、PaCO2、肺湿/干重比值(W/D),ELISA法检测血浆细胞因子IL-1、IL-8含量,HE染色观察肺组织病理学改变。结果:和对照组比较,实验组血中细胞因子IL-1在6h、24h组升高;细胞因子IL-8在6h组、24h组、48h组升高。6h组、24h组、48h组氧合指数<200mmHg。结论:兔油酸ARDS模型48h内稳定,炎性细胞和IL-1、IL-8可能是导致ARDS的发生和发展主要原因之一。
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| 关 键 词： | 油酸 呼吸窘迫综合征ARDS IL-1 IL-8 兔 |
The Stability and Changes of IL-1, IL-10 in Plasma of New ZealandRabbits with Acute Respiratory Distress Syndrome |
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| LI Ying-zhuo,ZHANG Zhi-pei,FAN Chong-xi,WANG Jian,NI Yun-feng,DENG Ying-chun,YANG Jing,LI Xiao-fei,CHENG Qing-shu. The Stability and Changes of IL-1, IL-10 in Plasma of New ZealandRabbits with Acute Respiratory Distress Syndrome[J]. Progress in Modern Biomedicine, 2011, 11(4): 637-641 |
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| Authors: | LI Ying-zhuo ZHANG Zhi-pei FAN Chong-xi WANG Jian NI Yun-feng DENG Ying-chun YANG Jing LI Xiao-fei CHENG Qing-shu |
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| Affiliation: | LI Ying-zhuo,ZHANG Zhi-pei,FAN Chong-xi,WANG Jian,NI Yun-feng,DENG Ying-chun,YANG Jing,LI Xiao-fei,CHENG Qing-shu(Department of Thoracic Surgery,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,Shaanxi,China) |
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| Abstract: | Objective:To investigate the stability and the changes of IL-1,IL-10 in plasma of New Zealand rabbits with acute res-piratory distress syndrome(ARDS) induced by oleic acid(OA) in 3 days.Methods:Thirty New Zealand rabbits were randomly divided into OA experimental groups which were injected with oleic acid(0.1mL/kg) via ear vein and control group which was injected with nor-mal saline(0.1mL/kg).Histopathology,wet weight/dry weight ratio(W/D) of the lung,arterial plasma PH,PaO2,PaCO2 were observed at 6h,24h,4... |
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| Keywords: | Oleic acid ARDS IL-1 IL-8 Rabbit |
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