血清抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体检测在甲状腺疾病诊断及甲亢预后判断中的价值

采用放免法检测甲状豚疾病患者抗甲状腺球蛋白抗体（ＴＧＡｂ）和抗甲状腺过氧化物酶抗体（ＴＰＯＡｂ）、并对部分Ｇｒａｖｅｓ病患者停药后随诊一年的结果进行分析。结果显示：（１）自身免疫性甲状腺疾病患者ＴＧＡｂ和ＴＰＯＡｂ活性及阳性率明显高于非ＡＩＴＤ，尤以桥本甲状腺炎为然。（２）ＧＤ治疗前及停药时ＴＧＡｂ和ＴＰＯＡｂ均阴性者与均阳性者停药一年内的复发率分别为０．５８３和０．２３１。（３）ＴＧＡｂ和ＴＰＯＡｂ均阴性，而停药时甲状腺刺激抗体（ＴＳＡｂ）阳性者，停药时ＧＤ复发的机率最大（０．９０９），提示ＴＧＡｂ和ＴＰＯＡｂ检测在ＡＩＴＤ诊断，鉴别诊断以及ＧＤ预后判断中具有重要的临床意义。

The Significance of Antithyroglobulin and Antithyroid Peroxidase Antibodies in Patients with Thyroid Diseases

Serum antithyroglobulin (TGAb) and antithyroid peroxidase antibodies (TPOAb) were measured by radioimmunoassay to determine their impact in the diagnosis of autoimmune thyroid diseases (AITD) and in the prediction of the relapse of Graves'disease (GD) after antiihyroid therapy. The results showed that (1) The activities and positivity for two antibodies were markedly higher in patients with AITD,especially in patients with Hashimoto's thyroiditis (HT); (2)The relapse of GD within one year after treatment was significantly higher in GD patients with negative TGAb and TPOAb before and at the end of therapy than in patients with positive TGAb and TPOAb; (3)The patients with positive thyroid stimulating antibody(TSAb) at the time of ceasation of treatment and negative TGAb and TPOAb were much easier to relapse after withdrawal of antithyroid drugs.