盐酸托烷思琼预防脑动脉瘤栓塞术后恶心呕吐的观察

目的:观察盐酸托烷思琼对预防脑动脉瘤栓塞术患者术后恶心呕吐(PONV)的有效性和安全性。方法:选择行颅内动脉瘤栓塞术患者45例,随机分为3组,每组15例,于手术结束前30分钟A组患者缓慢静注盐酸托烷思琼5mg,B组患者缓慢静注盐酸托烷思琼3mg,C组患者给予生理盐水。术后观察并记录以下指标:(1)术后24h内恶心呕吐发生率及强度;(2)术后2、8h镇静评分(OAA/S);(3)术后2、8h平均动脉压(MAP),心率(HR);(4)各组不良反应的发生情况。结果:术后24h内两治疗组恶心呕吐发生率显著低于对照组,差异有统计学意义(P<0.05或P<0.01)。托烷思琼5mg组恶心呕吐发生率略低于3mg组,但差异无统计学意义(P>0.05)。结论:托烷思琼可降低脑动脉瘤栓塞术患者术后恶心呕吐的发生率。托烷思琼3mg不仅可以减少药物用量,而且能减少副作用的发生,是一种经济、有效、安全的止吐方法。

Effect of Tropisetron on PONV in Patients Undergoing Endovascular embolization.

Objective: To evaluate the safety and efficacy of tropisetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing endovascular embolization. Methods: 45 patients with cerebral aneurysm scheduled for endovascular embolization. were randomly allocated into three groups: group tropisetron of 5mg(group A), group tropisetron of 3mg(group B),normal saline study group (group C). The drugs were administered intravenously about 30 minuts before the operations were ended. The numbers of patients with PONV , the scores of PONV and side effect were studied respectively. Result: The incidence of nausea and vomiting was significantly lower in group A and group B than that in group C in 24h postoperatively (P<0.05) while there was no significant difference between group A and group B. Conclusion: Tropisetron can reduce the incidence of PONV in patients undergoing endovascular treatment. Tropisetron 3mg had the better efficacy and less side effects on preventing PONV.