两个地区东方田鼠基因组RAPD分析比较研究

为了建立一种与临床上冠脉搭桥手术和经皮腔内冠状动脉成形术（PTCA）等病理过程相似的血管再狭窄模型，探讨血管再构和新内膜形成的机理，及在血管再狭窄中所起的重要作用，我们用不同品系（BALB／cA和C57BL／6J）小鼠的左颈总动脉进行了结扎，在2周和4周后，分别作病理学观察，结果发现两种品系小鼠产生了不同的病理结果，C57BL／6J小鼠有明显的血管狭窄和炎症细胞浸润，而BALB／cA小鼠虽有炎症细胞的浸润，但血管的内膜无炎症细胞浸润，也无血管狭窄表现，结果提示：血管再狭窄是血管再构和新内膜形成的共同原因。

Genomic RAPD Analysis andComparative Study on Fiel d Voles (Microtus Fortis)from Two Regions in China

Restenosis is one of the major limitations of PTCA and CABG, it can be assumed as a combination of neointima formation and arterial remodeling in response to injury. We recently established model with mice BALB/cA and C57BL/6J. After ligation of the left common carotid artery just proximal to the bifurcation resulting in 90% reduction of lumen area by a combination of intimal hyperplasia together with decreased diameter. In this study, neointima formation in C57BL/6J mice and BALB/cA mice was compared. Two and four weeks after the ligation, leukocyte infiltration was observed in the developing neointima, a 90% reduction of luminal area was observed in C57BL/6J; While in BALB/cA no neointima formation was observed. Conclusion: Vascular remodeling with neointima formation was the cause of restenosis, presumably by mediating leukocyte recruitment and the interaction between platelets and leukocytes.