204株铜绿假单胞菌耐药性分析

目的:对2007至2009年分离出的204株铜绿假单胞菌的药物敏感性进行回顾性分析,为临床合理用药提供依据。方法:对2007至2009年分离出的204株铜绿假单胞菌进行美罗培南、头孢哌酮/舒巴坦、头孢他啶、氨曲南、亚胺培南、哌拉西林/他唑巴坦、左氧氟沙星及头孢吡肟8种药物耐药性分析(应用纸片扩散法),操作和判定参照2006年美国临床试验室标准委员会标准。结果:铜绿假单胞菌对常用抗生素的耐药率均呈逐年上升趋势,对碳青酶烯类抗生素(如亚胺培南)的耐药率相对较低。结论:亚胺培南可作为对铜绿假单胞菌感染经验性治疗的首选药物,临床用药可根据抗生素敏感率统计结果来选用抗生素,做到个体化治疗。

Analysis of antibiotic resistance of 204 pseudomonas aeruginosa

Objective: For 2007 to 2009,204 isolated strains of pseudomonas aeruginosa susceptibility were retrospectively analyzed to provide a basis for the clinical use of drugs.Methods: For 2007 to 2009,204 isolated strains of pseudomonas aeruginosa to meropenem,cefoperazone/sulbactam,ceftazidime,aztreonam,imipenem,piperacillin/tazobactam,levofloxacin and cefepime 8 drugs resistances were analyzed.Disk diffusion method was used,operation and determination referenced 2006 American Society of Clinical Laboratory Standards Board standards.Results: pseudomonas aeruginosa resistance rate to commonly used antibiotics showed an upward trend year by year,the carbapenem antibiotics(such as imipenem) resistance rate was relatively low.Conclusion: Imipenem can be used as empirical therapy for pseudomonas aeruginosa infection in the drug of choice.Antibiotics can be clinically used according to the sensitivity rate statistics results of use of antibiotics,so that individual treatment.