Structural abnormalities of autosomal chromosomes in the male partner do not influence fertilization and early development of embryos after intracytoplasmic sperm injection |
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Authors: | Yoshida A; Araki Y; Motoyama M; Kim SY; Sung H; Araki S; Miura K; Shirai M |
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Affiliation: | The Institute of Advanced Medical Technology Central Clinic, Yakushiji, Tochigi-ken, Japan. |
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Abstract: | The objective of this study was to determine whether or not abnormalities
in the autosomal structure of the male partner have any influence on
fertilization and early embryo development after intracytoplasmic sperm
injection (ICSI). Thirty-seven couples in whom the male partners were
examined by the same andrologist were included in this study. Six couples
(group I) in whom the male partner possessed autosomal structural
abnormality underwent seven ICSI cycles. As a control group, 31 couples
(group II) in which the male partner was karyotypically normal underwent 41
ICSI cycles. Although the normal fertilization rates seen in group I were
significantly higher than those in group II (P < 0.05), there was no
significant difference in the cleavage rates between the two groups. We did
not perform the analysis of the female partner's chromosomes, but we
surmise that structural autosomal abnormalities in the male partner do not
adversely influence fertilization at ICSI and early development of embryos.
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