基于18F-FDG PET及主观认知下降问卷-9诊断主观认知下降

目的 观察基于¹⁸F-FDG PET及主观认知下降问卷-9(SCD-Q9)诊断主观认知下降(SCD)的价值。方法 回顾性分析50例SCD患者(SCD组)及49名健康人(对照组)头颅¹⁸F-FDG PET及主观认知下降问卷-9(SCD-Q9)评估结果;对PET图像行全脑体素定量分析,以脑桥为参考计算标准摄取值比值(SUVR),观察SCD组葡萄糖代谢模式,分析SCD组SUVR减低脑区,评估SUVR减低联合SCD-Q9诊断SCD的价值。结果 相比对照组,SCD组左内侧额上回及右侧额上回SUVR显著减低、左侧距状回SUVR显著升高(GRF校正,体素水平P均＜0.01,团簇水平P均＜0.05)。以左内侧额上回+右侧额上回SUVR联合诊断SCD的敏感度、特异度及曲线下面积(AUC)分别为54.00%、77.60%及0.660,进一步联合SCD-Q9分别为86.00%、75.50%及0.840,其间AUC差异有统计学意义(P＜0.05)。结论 ¹⁸F-FDG PET脑代谢显像可显示SCD脑代谢异常模式;联合SCD-Q9有助于诊断SCD。

18F-FDG PET and 9-item subjective cognitive decline questionnaire for diagnosing subjective cognitive decline

Objective To observe the value of ¹⁸F-FDG PET and 9-item subjective cognitive decline questionnaire (SCD-Q9) for diagnosing subjective cognitive decline (SCD). Methods Data of ¹⁸F-FDG PET images as well as evaluation results of SCD-Q9 of 50 SCD patients (SCD group) and 49 healthy subjects (control group) were retrospectively analyzed. Taken the pons as reference, whole-brain voxel quantification was performed to calculate the standard uptake value ratio (SUVR). The abnormal glucose metabolism pattern of SCD was observed, and the diagnostic efficacy of SUVR reduction brain regions combining with SCD-Q9 for SCD was analyzed. Results Compared with control group, SUVR of left medial superior frontal gyrus and right superior frontal gyrus significantly decreased, while of left calcarine increased in SCD group (GRF corrected, all P＜0.01 for voxel level, all P＜0.05 for cluster level). The sensitivity, specificity and area under the curve (AUC) of left medial superior frontal gyrus and right superior frontal gyrus for diagnosing SCD was 54.00%, 77.60% and 0.660, respectively, while combining with SCD-Q9 was 86.00%, 75.50% and 0.840, respectively, with significantly different AUC (P＜0.05). Conclusion ¹⁸F-FDG PET brain metabolism imaging could display abnormal metabolic patterns of SCD, which combining with SCD-Q9 was helpful for diagnosing SCD.