| 2,6-二氨基-3,5-二硝基吡嗪-1-氧化物的合成 |
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| 引用本文： | 赵晓锋,刘祖亮,姚其正,成健,董岩.2,6-二氨基-3,5-二硝基吡嗪-1-氧化物的合成[J].火炸药学报,2012,35(3):15-17. |
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| 作者姓名： | 赵晓锋 刘祖亮 姚其正 成健 董岩 |
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| 作者单位： | 1. 南京理工大学化工学院,江苏南京,210094
2. 中国药科大学药学院,江苏南京,210094 |
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| 摘 要： | 以亚氨基二乙腈为起始原料,经过亚硝基化、环合、硝化三步反应得到2,6-二氨基-3,5-二硝基吡嗪-1-氧化物(LLM-105)。确定了硝化2,6-二氨基吡嗪-1-氧化物(DAPO)制备LLM-105的最佳工艺条件为:反应温度25℃,反应时间5h,用发烟硝酸或硝酸钾向发烟硫酸和2,6-二氨基吡嗪-1-氧化物混合物中加料的工艺路线,总产率为35%。用1 H NMR,IR,MS对DAPO和LLM-105的结构进行了表征,推测了DAPO环化反应历程。
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| 关 键 词： | 有机化学 -二氨基- -二硝基吡嗪--氧化物 亚氨基二乙腈 含能材料 |
Synthesis of 2,6-Diamino-3,5-dinitropyrazine-1-oxide |
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| ZHAO Xiao-feng
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LIU Zu-liang
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YAO Qi-zheng
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CHENG Jian
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DONG Yan.Synthesis of 2,6-Diamino-3,5-dinitropyrazine-1-oxide[J].Chinese Journal of Explosives & Propellants,2012,35(3):15-17. |
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| Authors: | ZHAO Xiao-feng LIU Zu-liang YAO Qi-zheng CHENG Jian DONG Yan |
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| Affiliation: | 1(1.School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China;2.School of Pharmacy,China Pharmaceutical University,Nanjing 210094,China) |
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| Abstract: | A new synthetic method using iminodiacetonitrile as the starting material in three steps including nitrosylation,cyclization and nitration was designed to prepare 2,6-diamino-3,5-dinitropyrazine-1-oxide(LLM-105).The optimal reaction conditions for preparing LLM-105via 2,6-diamino-pyrazine-1-oxide(DAPO)were as follows:the reaction temperature 25℃,the reaction time 5hand fuming nitrate acid or potassium nitrate added to the mixture of fuming sulfuric acid and DAPO with total yield of 35%.The structures of DAPO and LLM-105were determined by 1 H NMR,IR,MS spectra.The mechanism of DAPO cyclization reaction was speculated. |
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| Keywords: | organic chemistry 2 6-diamino-3 5-dinitropyrazine-1-oxide iminodiacetonitrile energetic material |
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