2007年安徽省大肠埃希菌耐药性监测

目的了解2007年安徽省大肠埃希菌的耐药状况。方法采用国际标准平皿琼脂对倍稀释法，对2007年9月份从安徽33家医院临床分离的354株非重复的大肠埃希菌进行体外药敏实验，测定细菌的最低抑菌浓度（MIC），并按照美国临床实验室标准化委员会（CLSI）2007年版标准，计算细菌对抗菌药物的敏感率、中介率和耐药率。结果354株大肠埃希菌主要分离于痰和呼吸道分泌物，药敏结果显示该细菌对哌拉西林／三唑巴坦的敏感率明显高于其他头孢类抗菌药物；碳青霉烯类抗菌药物的抗菌活性最强。结论临床上应合理应用抗菌药物，并应加强细菌耐药性监测，以防止细菌耐药性的蔓延。

Resistance surveillance of Escherichia coli in Anhui province in 2007

Objective To analyze the surveillance data on the resistance of Escherichia coli in Anhui province in september 2005.Methods Data on bacterial susceptibility testing from 354 clinical non-repeated strains of Escherichia coli and collected from 33 hospitals in Anhui province was performed by routine custom dilution MIC method according to the CLSI (2007) guidelines, and detected the resistance, intermediate and susceptible rates of bacteria to antimicrobial agents respectively.Results 354 strains of Escherichia coli were mainly isolated from sputum and secretion of respiratory tract. Susceptible rate of bacteria to piperacillin-tazobactam was higher than other cephalosporins. Carbapenems were the most potent antimicrobial agents.Conclusion In order to control bacterial resistance, rationally choosing antimicrobial agents in the treatment of bacterial infections and strengthening efforts in monitoring of bacterial resistance were compulsory needed.