IL-18 Receptor Expression on Epithelial Cells is Upregulated by TNF Alpha期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

IL-18 Receptor Expression on Epithelial Cells is Upregulated by TNF Alpha

Authors:	Eli?ka?Krásná,Libor?Kolesár,Antonij?Slav?ev,?árka?Valhová,Bohumíra?Kronosová,Marcela?Jare?ová,Ilja?St?í? author-information" > author-information__contact u-icon-before" > mailto:ilja.striz@ikem.cz" title=" ilja.striz@ikem.cz" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;(2) Department of Immunology, Institute for Clinical and Experimental Medicine (IKEM), Vídeňská 1958/9, 140 21 Prague 4, Czech Republic

Abstract:	IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release.

Keywords:	IL-18 IL-18R epithelial cells cytokines
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