TiSiW12O40／TiO2催化合成氯乙酸异丙酯

首次以固载杂多酸盐ＴｉＳｉＷ１２Ｏ４０／ＴｉＯ２为多相催化剂，通过氯乙酸与异丙醇酯化反应合成了氯乙酸异丙酯。讨论了醇酸比、催化剂用量以及反应时间等因素对产率的影响。实验结果表明：ＴｉＳｉＷ１２Ｏ４０／ＴｉＯ２具有良好的催化活性。在醇酸物质的量比为１．３：１．０、催化剂用量为反应物料总量的１．５％、反应时间２．０ｈ、反应温度９０～１０８℃的条件下，氯乙酸异丙酯的产率可达７３．３％。

Synthesis of Isopropyl Chloroacetate Catalyzed by TiSiW12O40/TiO2

Isopropyl chloroacetate was synthesized by esterification of chloroacetic acid with iso-propanol using TiSiW12O40/TiO2 as heterogeneous catalyst- The effects of factors such as molar ratio of isopropanol to chloroacetic acid, amount of catalyst, and reaction time on the yield of isopropyl chloroacetate were discussed. The results showed that TiSiW12040/TiO2 was an excellent catalyst for synthesizing isopropyl chloroacetate. The yield of isopropyl chloroacetate was up to 73. 3% when mo-lar ratio of isopropanol to chloroacetic acid was 1. 3 : 1.0, amount of catalyst was 1. 50%(on total amount of reaction mass) , reaction temperature was 90-108 C , and reaction time was 2. 0 h.