Organic Nanocrystals Based on a Solid-emission-tunable AIEgen for Cell Imaging |
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Authors: | YANG Liming GUO Lixin YU Hao WANG Guan SUN Jiangman ZHANG Pengfei GU Xinggui TANG Ben Zhong |
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Affiliation: | Beijing Advanced Innovation Center for Soft Matter Science and Engineer-ing,College of Materials Science and Engineering,State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,P.R.China;Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS Key Laboratory of Health Informatics,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,P.R.China;Department of Chemistry,Hong Kong Branch of Chinese National Engi-neering Research Center for Tissue Restoration and Reconstruction,Institute for Advanced Study,The Hong Kong University of Science and Technology,Hong Kong,P.R.China |
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Abstract: | The development of fluorescent nanocrystals based on organic small molecules is of great importance in bioimaging due to the merits of easy modification, high brightness and excellent photostability, however suffering from the emission-detrimental aggregation-caused quenching(ACQ) effect. Herein, we successfully designed and synthesized an AIE-active di(N,N-dimethylaniline)-dibenzofulvene(named as NFTPE), which exhibits the crystallization-induced emission enhancement(CIEE) effect. Interestingly, two types of yellow- and orange-emissive crystals for NFTPE were obtained, exhibiting aggregation microenvironment-dependent emission tuning in the solid state. Single-crystal analysis and density functional theory(DFT) calculations reveal that different aggregation microenvironments result in the distinct molecular conformation for various emission. Excitingly, the crystallization of NFTPE in an aqueous solution under the assistance of amphiphilic PEG polymer matrices could be monitored in situ by the fluorescence changes, facilitating the preparation of NFTPE nanocrystals(NFTPE-NCs) by adjusting the aggregation microenvironment. The obtained NFTP-ENCs exhibit the superior performance in cell imaging in respect to high brightness, photostability, and biocompatibility, thus demon-strating the potential in bioimaging applications. |
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Keywords: | ggregation-induced emission(AIE) Crystallization-induced emission enhancement(CIEE) Aggregation microenviron-ment Nanocrystal Cell imaging |
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