21例T细胞大颗粒淋巴细胞白血病的临床分析及文献回顾 |
| |
引用本文: | 董玉婷,周敏然,李淼,马荷花,王冉,秦雪梅,陈春燕. 21例T细胞大颗粒淋巴细胞白血病的临床分析及文献回顾[J]. 中国肿瘤临床, 2020, 47(23): 1205-1209. DOI: 10.3969/j.issn.1000-8179.2020.23.186 |
| |
作者姓名: | 董玉婷 周敏然 李淼 马荷花 王冉 秦雪梅 陈春燕 |
| |
作者单位: | 山东大学齐鲁医院血液科(济南市 250012) |
| |
摘 要: | 目的:分析T细胞大颗粒淋巴细胞白血病(T-cell large granular lymphocytic leukemia,T-LGLL)患者的临床特征、治疗方案及生存情况。方法:回顾性分析2009年2月至2019年12月山东大学齐鲁医院收治的21例T-LGLL患者的临床及实验室检查资料,总结其临床特征、治疗方案及预后情况。结果:T-LGLL患者多为中老年男性,主要临床表现为乏力(61.9%)、感染(28.6%)、脾肿大(61.9%),6例患者合并自身免疫性疾病。T-LGLL患者血常规通常表现为白细胞减少(42.9%)和(或)贫血(71.4%),骨髓涂片可见大颗粒淋巴细胞增多,骨髓活检可见粒红系增生受抑,典型的T-LGLL免疫表型为CD3+CD4-CD8+CD57+CD16+,88.9%患者TCR基因重排阳性。T-LGLL通常疾病进展缓慢,免疫抑制治疗总有效率为60%,血液学完全缓解率为20%,部分缓解率为40%。结论:T-LGLL为一种以血细胞减少、骨髓及外周血中大颗粒淋巴细...
|
关 键 词: | T细胞大颗粒淋巴细胞白血病 血细胞减少 大颗粒淋巴细胞 免疫 |
收稿时间: | 2020-09-12 |
Clinical analysis of 21 cases of T-cell large granular lymphocytic leukemia and literature review |
| |
Affiliation: | Department of Blood Specialty, Qilu Hospital of Shandong University, Jinan 250012, China |
| |
Abstract: | Objective To summarize the clinical features, treatment options, and survival prognoses of patients with T-cell large granular lymphocytic leukemia (T-LGLL). Methods The clinical and laboratory examination data of 21 patients with T-LGLL admitted to Qilu Hospital of Shandong University from February 2009 to December 2019 were retrospectively analyzed, and the clinical characteristics, treatment options, and prognosis of T-LGLL were summarized. Results The majority of T-LGLL patients were middle-aged and elderly men. The main clinical manifestations included fatigue (61.9%), infection (28.6%), and splenomegaly (61.9%), and 6 cases combined with autoimmune diseases. Routine blood tests of T-LGLL patients usually revealed leukopenia (42.9%) and/or anemia (71.4%). Examination of bone marrow smears showed an increase in the number of large granular lymphocytes, and bone marrow biopsy demonstrated the suppression of granulocyte hyperplasia. The typical T-LGLL immunophenotype was CD3+ CD4- CD8+ CD57+ CD16+, with positivity for T-cell receptor gene rearrangement observed in 88.9% of cases. T-LGLL usually progresses slowly. The total effective rate of immunosuppressive therapy was 60%, with a complete hematological remission rate of 20% and a partial remission rate of 40%. Conclusions T-LGLL is a disease characterized by cytopenia and a clonal increase in large granular lymphocytes in bone marrow and peripheral blood. It is often complicated by autoimmune diseases. This disease progresses slowly, and the effect of first-line immunosuppressive treatment is acceptable. |
| |
Keywords: | |
|
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载免费的PDF全文 |
|