| 4-氯-2,5二氟苯甲酸的合成 |
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| 引用本文： | 赵昊昱. 4-氯-2,5二氟苯甲酸的合成[J]. 化学世界, 2011, 52(1): 30-32,45 |
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| 作者姓名： | 赵昊昱 |
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| 作者单位： | 常州工程职业技术学院化工系,江苏,常州,213164 |
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| 摘 要： | 提出了一种以2,5-二氟苯胺为原料,经Sandmeyer反应、溴化和格氏反应三步得到4-氟-2,5-二氟苯甲酸的合成方法.其中溴化反应的最佳反应条件为:n(2-氯1,4-二氟苯):,你、n(溴素)=1:1.13,n(2-氯1,4-二氟苯):n(无水三氯化铁)=1:0.03,溴化反应温度为30℃,反应时间为5h.三步总摩...
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| 关 键 词： | 4-氯-2 5-二氟笨甲酸 Sandmeyer反应 溴化反应 格氏反应 合成 |
Synthesis of 4-Chloro-2,5-difluorobenzoic Acid |
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| ZHAO Hao-yu. Synthesis of 4-Chloro-2,5-difluorobenzoic Acid[J]. Chemical World, 2011, 52(1): 30-32,45 |
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| Authors: | ZHAO Hao-yu |
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| Affiliation: | ZHAO Hao-yu(Changzhou Institute of Engineering Technology,Department of Chemical Engineering,Jiangsu Changzhou 213164,China) |
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| Abstract: | A synthesis method of 4-chloro-2,5-difluorobenzoic acid from 2,5-difluoroaniline by Sandmeyer reaction,bromination and Grignard reaction was proposed.The optimal reaction conditions of bromination were: n(2-chloro-1,4-difluorobenzene)∶n(Br_2)=1∶1.13,n(2-chloro-1,4-difluorobenzene)∶n(FeCl_3)=1∶0.03,bromination temperature=30 ℃,and bromination time=5 h.The overall yield was 31%,and the purity of product was 99.16%(HPLC).The structure of the product was confirmed by MS and ～1H NMR. |
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| Keywords: | 4-chloro-2 5-difluorobenzoic Sandmeyer reaction bromization Grignard reaction synthesis |
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