| 2-[3-氰基呋喃-2(5H)-亚基]丙二腈衍生物的合成及其对Pd2+的识别 |
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| 引用本文： | 钟克利,周璐璐,陈琳,汤立军,高雪,刘秀英,庞秀秀,燕小梅.2-[3-氰基呋喃-2(5H)-亚基]丙二腈衍生物的合成及其对Pd2+的识别[J].有机化学,2021(3):1124-1130. |
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| 作者姓名： | 钟克利 周璐璐 陈琳 汤立军 高雪 刘秀英 庞秀秀 燕小梅 |
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| 作者单位： | 渤海大学化学与材料工程学院;渤海大学食品科学与工程学院生鲜农产品贮藏加工及安全控制技术国家地方联合工程研究中心;大连医科大学检验医学院 |
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| 基金项目： | 国家自然科学基金(Nos.21878023,U1608222);辽宁省自然科学基金指导计划(Nos.2020-MS-289,20180551195);辽宁特聘教授支持计划资助项目。 |
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| 摘 要： | 通过两步反应合成了一种2-(3-氰基呋喃-2(5H)-亚甲基)丙二腈衍生物TCF-Pyn,该化合物在MeCN/磷酸缓冲容溶液(PBS)(V∶V=2∶8,PBS 2×10-2 mol/L,pH=7.4)混合溶液中能高选择性荧光"OFF-ON"识别Pd2+,发射波长达到近红外区(653 nm).该探针具有较好的抗干扰能力、较宽的pH适用范围(3~8)和较低的检测限(6.92μmol/L).应用研究表明,TCF-Pyn能检测真实水样中的Pd2+,并可对活细胞中的Pd2+进行荧光成像.
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| 关 键 词： | 荧光探针 近红外发射 识别 Pd2+ 细胞成像 |
Synthesis of 2-(3-Cyanofuran-2(5H)-ylidene)malononitrile Derivative and Its Recognition for Pd |
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| Keli Zhong,Lulu Zhou,Lin Chen,Lijun Tang,Xue Gao,Xiuying Liu,Xiuxiu Pang,Xiaomei Yan.Synthesis of 2-(3-Cyanofuran-2(5H)-ylidene)malononitrile Derivative and Its Recognition for Pd[J].Chinese Journal of Organic Chemistry,2021(3):1124-1130. |
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| Authors: | Keli Zhong Lulu Zhou Lin Chen Lijun Tang Xue Gao Xiuying Liu Xiuxiu Pang Xiaomei Yan |
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| Affiliation: | (College of Chemistry and Material Engineering,Bohai University,Jinzhou,Liaoning 121013;National&Local Joint Engineering Research Center of Storage,Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products,College of Food Science and Technology,Bohai University,Jinzhou,Liaoning 121013;College of Laboratory Medicine,Dalian Medical University,Dalian,Liaoning 116044) |
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| Abstract: | 2-(3-Cyano-furan-2(5 H)-methylene)malononitrile derivative(TCF-Pyn)was synthesized by a two-step reaction.Compound TCF-Pyn could recognize Pd2+with a high selectivity,"OFF-ON"fluorescent response and the near-infrared emission(653 nm)in Me CN/PBS(V∶V=2∶8,PBS 2×10-2 mol/L,pH=7.4)solution.The probe possesses a good antiinterference capability,a wide pH range(3~8)and a low detection limit(6.92μmol/L).The application research showed that TCF-Pyn could detect Pd2+in real water samples and fluorescent image Pd2+in living cells. |
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| Keywords: | fluorescent probe near-infrared emission recognition Pd2+ cell imaging |
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