| 左旋一二脱水伊地醇双甲磺酸酯抗肿瘤作用及毒性 |
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| 引用本文： | 韦焕英,姚树汉,周龙强,罗斌,李茂,刘元.左旋一二脱水伊地醇双甲磺酸酯抗肿瘤作用及毒性[J].癌症,1991(3). |
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| 作者姓名： | 韦焕英 姚树汉 周龙强 罗斌 李茂 刘元 |
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| 作者单位： | 广西中医药研究所，广西中医药研究所，广西中医药研究所，广西中医药研究所，广西中医药研究所，广西中医药研究所 南宁 530022，南宁 530022，南宁 530022，南宁 530022，南宁 530022，南宁 530022 |
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| 摘 要： | 左旋一二脱水伊地醇双甲磺酸酯对大鼠吉田肉瘤腹水型(YAS)及实体型(YSS),大鼠W_(256)有显著抗肿瘤作用,对小鼠淋巴细胞白血病L_(1210)及P_(388)有较好疗效,对黑色素瘤B_(16)、小鼠S_(180)(实体型及腹水型),艾氏腹水癌(EAC)以及小鼠肝癌腹水型(HepA)也有抗瘤活性。对L_(1210)细胞有较强杀灭作用。小鼠一次给药,腹腔注射LD 50为628mg/kg;灌胃给药LD 50为572mg/kg。对狗的毒性主要表现为白细胞及血小板减少,对大鼠的白细胞影响较轻。
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| 关 键 词： | 左旋一二脱水伊地醇双甲磺酸酯 抗肿瘤作用 毒性 |
ANTITUMOR ACTIVITY AND TOXICITY OF 1,6-DIMESYL- 2 3-4. 5-DIANHYDRO-L-IDITOL IDITOL |
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| WEI Huan-ying YAO Shu-han ZHOU Lons-quiangLOU Bin LI Mao LIU Yuan.ANTITUMOR ACTIVITY AND TOXICITY OF 1,6-DIMESYL- 2 3-4. 5-DIANHYDRO-L-IDITOL IDITOL[J].Chinese Journal of Cancer,1991(3). |
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| Authors: | WEI Huan-ying YAO Shu-han ZHOU Lons-quiangLOU Bin LI Mao LIU Yuan |
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| Abstract: | l,6-Dimesyl-2,3- 4,5- dianhydro-L-iditol(DMDATI)was effectiveagainst w256,Yoshida subcutaneous and ascites sarcoma (YSS and YAS)of rats, S180, melanoma B16, EAC, HepA, L1210 and P388 of mice in vivo,among them W256,YSS and YAS showed higher sensitivity.DM DAI possessed cell killing effect on theL1 21 0cell. LD50 of DMDAI was 628(539-732)mg/kg forsingle ip injection and 572(456-717)mg/kg lor single ig adminstration in mice. The main toxicities were emaciation, diarrhoea and shrinkage of spleen in mice. Decrease of peripheral blood white cell and platelet Counts was observed for long-term toxicity test in dogs. Histological examination revealed depressed bone marrow, atrophy of the folliculi of spleen and hemorrhage in the intestinal mucosa. The pathologic signs could be recovered after withdrawal of the drug. |
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| Keywords: | 1 6-Dimesyl -2 3-4 5- dianhydro-L-iditol Antitumor activity Toxicity |
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