| 一种生物素改性聚乳酸生物材料的制备与性能研究 |
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| 引用本文： | 严好,潘君,江伟民,张晓喜,王远亮.一种生物素改性聚乳酸生物材料的制备与性能研究[J].功能材料,2011,42(3):399-403. |
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| 作者姓名： | 严好 潘君 江伟民 张晓喜 王远亮 |
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| 作者单位： | 重庆大学生物工程学院生物材料与仿生工程中心生物流变科学与技术教育部重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(10972243) |
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| 摘 要： | 研究试图通过本体改性,将生物素接枝到聚乙二醇接枝聚乳酸(PPLA)上,以改善聚乳酸微球在药物缓释应用中血液循环时间短和无主动靶向性的缺点.在本实验室制备的聚乙二醇接枝改性聚乳酸的基础之上,采用N-羟基琥珀酰亚胺活化酯法,将生物素接枝到PPLA上,制备生物素改性聚乳酸(BPLA),通过茚三酮显色、核磁共振(1H-NMR)...
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| 关 键 词： | 聚乳酸 生物素 亲和素 生物活性 药物缓释 |
The preparation and property of a poly(lactic acid)biomaterial modified by biotin |
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| YAN Hao,PAN Jun,JIANG Wei-min,ZHANG Xiao-xi,WANG Yuan-liang.The preparation and property of a poly(lactic acid)biomaterial modified by biotin[J].Journal of Functional Materials,2011,42(3):399-403. |
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| Authors: | YAN Hao PAN Jun JIANG Wei-min ZHANG Xiao-xi WANG Yuan-liang |
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| Affiliation: | YAN Hao,PAN Jun,JIANG Wei-min,ZHANG Xiao-xi,WANG Yuan-liang (The Key Laboratory of Biorheology Science and Technology under Ministry of Education,Biomaterials and Inspired Engineering Center,College of Biological Engineering,Chongqing University,Chongqing 400030,China) |
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| Abstract: | The aim of this research is to overcome the drawbacks of PLA in drug delivery system,which are short blood circulation time and non-active targeting.Based on PEG-graft-PLA(PPLA) developed in our lab,biotin was grafted onto PLA to produce BPLA by NHS-activated method.The ninhydrin coloration,1H-NMR,DSC,water contact angle test,fluorescence labeled protein absorption test were used to characterize BPLA.Results from ninhydrin coloration,1H-NMR,DSC,water contact angle test showed the biotin had been covalently ... |
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| Keywords: | poly(lactic acid) biotin avidin bioactivity drug delivery |
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