阻塞型睡眠呼吸暂停低通气综合征患者海马MRS参数与认知功能的相关性

目的 探讨阻塞型睡眠呼吸暂停低通气综合征（OSAHS）患者海马MRS成像参数与认知功能之间的相关性。方法 对31例OSAHS患者（OSAHS组）及28名健康志愿者（对照组）行单体素MRS检查，检测双侧海马NAA、Cho和Cr峰值，计算NAA/Cr、Cho/Cr、NAA/Cho；采用蒙特利尔认知评估量表（MoCA）和简易智能状态量表（MMSE）评估认知功能，分析双侧海马NAA/Cr、Cho/Cr、NAA/Cho与MoCA、MMSE评分间的相关性。结果 OSAHS组双侧海马Cho/Cr较对照组增高，NAA/Cho较对照组减低（P均<0.05），NAA/Cr差异无统计学意义（P均>0.05）。OSAHS患者双侧海马Cho/Cr与MoCA、MMSE评分呈负相关（P均<0.05），NAA/Cho与MMSE评分呈正相关（P均<0.05）。结论 OSAHS患者双侧海马MRS参数与认知功能相关，可作为OSAHS患者认知功能损害的神经影像学标记。

Correlation of hippocampal MRS metabolites and cognitive function in patients with obstructive sleep apnea hypopnea syndrome

Objective To explore the correlation of hippocampal MRS metabolites and neurocognitive function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Single voxel proton MRS was performed on 31 patients with OSAHS (OSAHS group) and 28 healthy volunteers (control group).NAA, Cho and Cr peak in bilateral hippocampus were detected, and NAA/Cr, Cho/Cr and NAA/Cho were calculated. Montreal cognitive assessment scale (MoCA) and simple intelligent state scale (MMSE) were used to assess cognitive function, then to analyze the correlation of NAA/Cr, Cho/Cr, NAA/Cho and MoCA, MMSE scores in bilateral hippocampus. Results Cho/Cr in bilateral hippocampus were higher in OSAHS group than in control group, while NAA/Cho in OSAHS group were lower than in control group (all P<0.05). There was no significant difference of NAA/Cr between OSAHS group and control group in bilateral hippocampus (all P>0.05). Cho/Cr in bilateral hippocampus of OSAHS patients were negatively correlated with MoCA and MMSE scores (all P<0.05), while NAA/Cho were positively correlated with MMSE scores (all P<0.05). Conclusion MRS metabolites of bilateral hippocampus in OSAHS patients are correlated with cognitive function, which can be used as neuroimaging markers for cognitive impairment in OSAHS patients.