| 聚(乳酸-酪氨酸)的合成及表征 |
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| 引用本文： | 白晓丹,樊国栋,李甜甜.聚(乳酸-酪氨酸)的合成及表征[J].功能材料,2012,43(6):681-683,687. |
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| 作者姓名： | 白晓丹 樊国栋 李甜甜 |
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| 作者单位： | 1. 吉首大学植物资源保护与利用湖南省高校重点实验室,湖南吉首,416000
2. 吉首大学化学化工学院,湖南吉首,416000 |
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| 基金项目： | 陕西省科技攻关资助项目，陕西省教育厅重点实验室重点科研计划资助项目 |
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| 摘 要： | 以乳酸(D,L-LA)和L-酪氨酸(Tyr)为原料n(D,L-LA)/n(Tyr)=95/5],采用梯度升温法,通过直接熔融缩聚合成了系列聚(乳酸-酪氨酸)共聚物(PLA-co-Tyr)。最佳工艺条件为压力0.095MPa,催化剂Sn(Cl)2用量为0.4%(质量分数),聚合温度170℃,反应10h。用特性粘度测试、FT-IR、1 H-NMR、GPC、XRD、DSC等对其进行表征,结果表明,此方法操作简单且成本低廉,系列共聚物与PLA相比,分子链中引入了活性基团,具有较小的Tg,结晶度有所降低,并且通过控制酪氨酸的加入量可以调节聚合物的结晶度。该聚合物分子量能满足用作药物缓释试剂的要求。
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| 关 键 词： | 聚乳酸 D L-酪氨酸 直接熔融缩聚 梯度升温法 药物缓释体系 |
Synthesis and characterization of poly（lactic acid-co-L-tyrosine） |
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| BAI Xiao-dan,FAN Guo-dong,LI Tian-tian.Synthesis and characterization of poly（lactic acid-co-L-tyrosine）[J].Journal of Functional Materials,2012,43(6):681-683,687. |
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| Authors: | BAI Xiao-dan FAN Guo-dong LI Tian-tian |
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| Affiliation: | (Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China) |
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| Abstract: | The poly(lactic acid-co-L-tyrosine) copolymers(PLA-co-Tyr) were synthesized via directly melt polycondensation with lactic acid(D,L-LA) and L-tyrosine(Tyr) as raw material using linear heating method.The best synthesis conditions were pressure 0.095 MPa,catalyst dosage 0.4%(mass fraction),polymerization temperature of 170℃ and polymerization time 10h.The copolymers were characterized by viscosity-average molecular weight,FT-IR,1H-NMR,GPC,XRD and DSC.The results demonstrate that the new method with easier steps is cheaper.Compared with PLA,it has lower Tg and by controlling the amount of the tyrosine,the crystallinity of the copolymer can be adjusted.The copolymers could meet the demand of drug delivery carrier material. |
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| Keywords: | polylactic acid L-tyrosine direct melt polycondensation gradient temperature method drug deliverysystems |
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