A facile and efficient ultrasound-assisted synthesis of novel dispiroheterocycles through 1,3-dipolar cycloaddition reactions |
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| Authors: | Hu Yu Zou Yi Wu Hui Shi Daqing |
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| Affiliation: | a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China
b School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, PR China |
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| Abstract: | A facile and efficient one-pot three-component procedure for synthesis of novel dispirooxindolecyclopyrrolo1,2-c]thiazole-6,5′-thiazolidine] derivatives without any catalysts under ultrasonic condition has been developed. Combining with the advantages of sonochemistry, such as mild reaction conditions, good yield and short reaction times, we have made a progress on construction of novel disiproheterocyclic compounds via the 1,3-dipolar cycloaddition of azomethine ylides. Several experiments were especially carried out for investigating the acceleration mechanism of ultrasound on the cycloaddition. |
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| Keywords: | Dispiroheterocyclic compound 1 3-Dipolar cycloaddition Azomethine ylide Ultrasound |
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