| 糖肾安对糖基化抑制作用的体外研究 |
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| 引用本文： | 苗春生,赵丽艳,赵雪梅,张秀云,李才. 糖肾安对糖基化抑制作用的体外研究[J]. 吉林大学学报(医学版), 2003, 29(6): 745-747 |
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| 作者姓名： | 苗春生 赵丽艳 赵雪梅 张秀云 李才 |
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| 作者单位： | 1. 吉林大学再生医学科学研究所病理学研究室,吉林,长春130021
2. 吉林大学第二医院检验科 |
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| 基金项目： | 卫生部科研项目;94212,962181; |
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| 摘 要： | 目的 :研究中草药复方糖肾安对体外糖基化的抑制作用。方法 :正常大鼠被随机分为对照组、糖肾安组和氨基胍组 ,分别灌服饮用水、糖肾安 ( 6g· kg-1 )和氨基胍 ( 2 5 mg· kg-1 ) ,4d后收集各组动物血清 ,观察这些含药血清对体外糖基化的抑制作用。结果 :与阳性药氨基胍相比 ,灌服糖肾安的大鼠血清对体外糖基化反应有明显的抑制作用 ,相对抑制率为 1 0 2 .2 %。结论 :糖肾安对糖基化反应有明显抑制作用
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| 关 键 词： | 血清药理学 中草药 糖肾安 糖基化 大鼠,Wistar |
| 文章编号： | 1671-587X(2003)06-0745-03 |
| 修稿时间： | 2002-08-03 |
Study on Inhibitory Effect of Tangshen′an on Glycation in Vitro |
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| MIAO Chun sheng ,ZHAO Li yan ,ZHAO Xue mei ,ZHANG Xiu yun ,LI Cai. Study on Inhibitory Effect of Tangshen′an on Glycation in Vitro[J]. Journal of Jilin University: Med Ed, 2003, 29(6): 745-747 |
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| Authors: | MIAO Chun sheng ZHAO Li yan ZHAO Xue mei ZHANG Xiu yun LI Cai |
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| Affiliation: | MIAO Chun sheng 1,ZHAO Li yan 2,ZHAO Xue mei 1,ZHANG Xiu yun 1,LI Cai 1* |
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| Abstract: | Objective: To investigate the inhibitory effect of Tangshen′an (TSA) on glycation in vitro .Methods:Normal rats were divided into control,TSA, and aminoguanidine groups. After drinking water, TSA (6 g·kg -1 ) and aminoguanidine (25 mg·kg -1 ) were administrated by gavage, respectively, for 4 days , the animal sera were collected. The inhibitory effect of the sera on glycation was observed in vitro glycation system.Results:As compared with positive drug aminoguanidine, the sera of rats treated with TSA showed significantly inhibitory effect on glycation in vitro , and the relative inhibitory rate was 102 2%.Conclusion:TSA shows significantly inhibitory effect on glycation. |
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| Keywords: | Serum pharmacology Drugs,Chinese herbal Tangshen′an Glycosylation Rats, Wistar |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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