| 动物内毒素性发热时不同脑区组织cAMP含量的变化 |
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| 引用本文： | 孙连坤,杜葵琴,计国义,郭中钰.动物内毒素性发热时不同脑区组织cAMP含量的变化[J].吉林大学学报(医学版),1992(1). |
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| 作者姓名： | 孙连坤 杜葵琴 计国义 郭中钰 |
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| 作者单位： | 白求恩医科大学病理生理学教研室
(孙连坤，杜葵琴，计国义)，白求恩医科大学病理生理学教研室(郭中钰) |
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| 摘 要： | 本实验用精制大肠杆菌内毒素(ET)分别复制大鼠、家兔ET性发热模型,观察大鼠与家兔不同脑区组织(脑皮质、脑干、丘脑下部)cAMP含量的变化。结果发现:大鼠,家兔ET性发热时,丘脑下部cAMP含量明显增加,且与体温变化呈正相关关系;而脑皮质、脑干cAMP含量未见明显变化。作者推论:大鼠、家兔ET性发热都是由于丘脑下部cAMP含量增加所致,丘脑下部cAMP含量变化是体温波动的原因之一。cAMP可能是一重要的中枢性发热介质。
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| 关 键 词： | 发热 内毒素 环—磷酸腺苷 |
CHANGES OF CYCLIC AMP IN DIFFERENT CEREBRALAREAS IN ANIMALS DURING FEVERINDUCED BY ENDOTOXIN |
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| Sun Liankun,et at.CHANGES OF CYCLIC AMP IN DIFFERENT CEREBRALAREAS IN ANIMALS DURING FEVERINDUCED BY ENDOTOXIN[J].Journal of Jilin University: Med Ed,1992(1). |
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| Authors: | Sun Liankun et at |
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| Affiliation: | Department of Pathophysiology |
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| Abstract: | Rabbits and rats were used to induce fever by injection of refined E. Coli endo-toxin. Levels of cyclic adenosine phosphate (cAMP) in the cortex, brainstem and hypothalamus were assayed in these animals. Comparisons were made between rabbits and rats, as well as the cAMP levels among different cerebral areas.The results showed that during the endotoxin fever, levels of cAMP in the hypothalamus, but not the cortex and brainstem, significantly increased and were positively corelated to the body temperature changes in both rats and rabbits. The author considered that the endotoxin fever in rats and rabbits is due to an increase of cAMP in the hypothalamus, and this is responsible for the changes in body temperature. cAMP might be an important central transmitter for fever. |
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| Keywords: | Fever Endotoxin cAMP |
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