| 卡培他滨中有机残留溶剂的检测 |
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| 引用本文： | 益磊,单静静,周至美,耿武松,孟祥松,蒋磊.卡培他滨中有机残留溶剂的检测[J].中南药学,2013,11(1):60-62. |
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| 作者姓名： | 益磊 单静静 周至美 耿武松 孟祥松 蒋磊 |
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| 作者单位： | 1. 亳州市食品药品检验所,安徽亳州,236800
2. 安徽恒星制药有限公司,合肥,230000 |
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| 摘 要： | 目的建立气相色谱法测定卡培他滨原料药中二氯甲烷、乙醇、甲醇和乙酸乙酯4种有机溶剂。方法采用DB-624毛细管柱,FID检测器,以DMSO为溶剂。结果各有机溶剂的平均加样回收率为93.7%～97.6%,RSD为2.5%～3.7%。结论该方法稳定准确,可用于卡培他滨中有机溶剂残留的检测。
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| 关 键 词： | 卡培他滨 有机溶剂残留 气相色谱 检测 |
Determination of residual organic solvents in capecitabine |
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| YI Lei
,
SHAN Jing-jing
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ZHOU Zhi-mei
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GENG Wu-song
,
MENG Xiang-song
,
JIANG Lei.Determination of residual organic solvents in capecitabine[J].Central South Pharmacy,2013,11(1):60-62. |
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| Authors: | YI Lei SHAN Jing-jing ZHOU Zhi-mei GENG Wu-song MENG Xiang-song JIANG Lei |
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| Affiliation: | 1(1.Bozhou Institute for Food and Drug Control,Bozhou Anhui 236800;2.Anhui Healstar Pharmaceutical Co.Ltd,Hefei 230000) |
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| Abstract: | Objective To establish a GC method for the determination of residual organic volatitl solvents-dichloromethane,methanol,ethyl acetate and sthanolin tiotropium bromide in capecitabine.Methods A DB-624 capillary column was used,with FID as the detector and DMSO as the solvent.Results The average recoveries were 93.7%-97.6%,with RSDs of 2.5%-3.7%.Conclusion The method is stable and accurate,and can apply to the determination of the 4 residual organic solvents in capecitabine. |
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| Keywords: | capecitabine residual organic solvent GC determination |
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