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| 基于肝切除手术来源的成人肝细胞移植的临床应用 | |
| 引用本文： | 李灼日,毛先海,胡小萱,聂盛丹,石咏中,向华,吴金术,陈海鸥,杨建辉,曹友德. 基于肝切除手术来源的成人肝细胞移植的临床应用[J]. 中国现代手术学杂志, 2009, 13(4) |
| 作者姓名： | 李灼日 毛先海 胡小萱 聂盛丹 石咏中 向华 吴金术 陈海鸥 杨建辉 曹友德 |
| 作者单位： | 1. 湖南省人民医院肝胆外科,长沙,410005 2. 湖南省人民医院肝病内科,长沙,410005 3. 湖南省人民医院临床研究所,长沙,410005 4. 湖南省人民医院微创介入中心,长沙,410005 |
| 基金项目： | 湖南省科技厅2007年重点项目 |
| 摘 要： | 目的探讨成人肝细胞移植治疗肝衰竭的临床效果。方法从良性病变的外科肝切除组织中获取有活性的成人肝细胞,对2例肝衰竭患者采用股动脉插管介入法行脾脏内移植。结果2例患者在治疗后病情均得到一定程度的缓解,临床症状和生化指标明显改善,其肝功能有一定程度的恢复,但例1术后第3 d胆红素上升,术后第4 d出现肝昏迷而自动出院;例2于术后1周黄疸指数再次升高,术后40 d死亡。结论成人肝细胞脾脏内移植治疗肝衰竭,技术上安全可行,且具有一定临床疗效;如何增强移植后肝细胞的数量和功能将是维持受体肝功能持续改善的关键。 |
| 关 键 词： | 肝细胞 细胞移植 肝功能衰竭 |
Clinical Applications of the Adult Hepatocyte Transplantation Originated from the Intravital Hepatectomy |
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| LI Zhuo-ri,MAO Xian-hai,HU Xiao-xuan,NIE Sheng-dan,SHI Yong-zhong,XIANG Hua,WU Jin-shu,CHEN Hai-ou,YANG Jian-hui,CAO You-de. Clinical Applications of the Adult Hepatocyte Transplantation Originated from the Intravital Hepatectomy[J]. Chinese Journal of Modern Operative Surgery, 2009, 13(4) | |
| Authors: | LI Zhuo-ri MAO Xian-hai HU Xiao-xuan NIE Sheng-dan SHI Yong-zhong XIANG Hua WU Jin-shu CHEN Hai-ou YANG Jian-hui CAO You-de |
| Affiliation: | LI Zhuo-ri; MAO Xian-hai; HU Xiao-xuan; NIE Sheng-dan; SHI Yong-zhong; XIANG Hua; WU Jin-shu; CHEN Hai-ou; YANG Jian-hui; CAO You-de(Department of the Hepatobiliary Surgery; People's Hospital of Hunan Province; Changsha 410005; Hunan; China); |
| Abstract: | Objective To explore the clinical effects of the adult hepatocyte transplantation originated from the intravital hepatectomy. Method Two cases of acute liver failure were implanted the hepatocytes originated from the intravital hepatectomy into pulpa splenica by intervention therapy. Results The two cases both got the symptomatic and the biochemical relieve after the transplantation.But one case appeared the bilirubin increasing at the third day after operation,and later dismissed because of hepatic coma.Th... |
| Keywords: | hepatocytes cell transplantation liver failure |
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