| 叶酸受体靶向的聚乳酸共聚物的合成及性质 |
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| 引用本文： | 欧静,陈元维,罗祥林. 叶酸受体靶向的聚乳酸共聚物的合成及性质[J]. 功能材料, 2009, 40(2) |
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| 作者姓名： | 欧静 陈元维 罗祥林 |
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| 作者单位： | 四川大学,高分子科学与工程学院,四川,成都,610065;四川大学,高分子科学与工程学院,四川,成都,610065;四川大学高分子科学与工程国家重点实验室,四川,成都,610065 |
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| 摘 要： | 用氨基被保护的4-羟基-脯氨酸与L-丙交酯共聚合,得到含有活性氨基作为侧基的聚合物主链(PLLA-Hpr),通过DDC将叶酸与聚合物中的氨基反应,制得叶酸偶联的脯氨酸一乳酸共聚物(FA-PLLA-Hpr).采用1H-NMR、FT-IR确证了共聚物的结构,对比研究了共聚物的亲水性.结果表明成功地制备了叶酸受体靶向的聚乳酸共聚物.这种共聚物有望作为药物缓释领域的肿瘤靶向材料.
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| 关 键 词： | 叶酸 聚乳酸 偶联 亲水性 |
Synthesis and characterization of folate receptor targeted polylactic acid copolymer |
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| OU Jing,CHEN Yuan-wei,LUO Xiang-lin. Synthesis and characterization of folate receptor targeted polylactic acid copolymer[J]. Journal of Functional Materials, 2009, 40(2) |
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| Authors: | OU Jing CHEN Yuan-wei LUO Xiang-lin |
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| Affiliation: | 1.College of Polymer Science and Engineering;Sichuan University;Chengdu 610065;China;2.State Key Laboratory of Polymer Materials Engineering;China |
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| Abstract: | A polymer main chain(PLLA-Hpr)with active amido groups as its side chain was synthesized by the copolymerization of L-lactide and 4-hydroxy-L-proline with protected amido.Folate was conjugated to PLA-Hpr by the reaction between carboxyl of folate and amido groups in PLLA-Hpr with DCC to produce copolymer FA-PLLA-Hpr.The structure of the obtained copolymers were proved by 1H-NMR and FT-IR and their hydrophilicity was learned.contrastively.The results showed that folate receptor targeted polylactic acid copol... |
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| Keywords: | folate polylactic acid copolymer material targeted tumors hydrophilicity |
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