2型糖尿病患者尿单核细胞趋化蛋白-1排泄的变化及其意义

目的观察2型糖尿病（type 2 diabetes mellitus，T2DM）患者尿单核细胞趋化蛋白-1（MCP-1）排泄的变化并分析尿MCP一1排泄与尿白蛋白排泄的关系。方法正常对照组20例（A组），56例2型糖尿病患者据其尿白蛋白／肌酐比值（the ratio of urinary albumin to creatinine ACR：mg·g^-1·Cr^-1）分为正常白蛋白尿组（B组，N=21），微量白蛋白尿组（C组，N=20），临床白蛋白尿组（D组，N=17）。检测所有人选者尿MCP-1／尿肌酐（Ucr）比值及其相关因素。结果与对照组比较，B组、C组、D组在年龄、性别、体重指数方面差异无统计学意义；与A组比较，B组尿MCP-1／Ucr水平显著升高（P〈0．01），C组和D组尿MCP-1／Ucr水平进一步升高（P〈0．01）；尿MCP-1／Ucr水平与UAIb／Ucr、HbAlc、血清TC和TG呈正相关。结论2型糖尿病患者尿MCP-1排泄增加，并与糖尿病。肾病的病情程度有关。

Changes and their significance of urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics

Objective To observe the changes of the urinary MCP-1 excretion, and analyse its relationship with albuminuria in T2DM. Methods 20 normal controls （group A, N = 20） and 56 diabetics were enrolled in this study, with diabetics, were divided into 3 groups according to （ACR： mg·g^-1· Cr^-1 ） ： normoalbnminuria group （group B, N = 21 ）, micro-albuminuria group （group C, N = 20）, and macroalbuminuria group （group D, N = 17）. Urinary MCP-1 were measured by enzyme-linked immunosorbent assay （ELISA）. Results There were no significant differences between normal control group and group B, C and D in age, sex, and body mass index; Compared with group A, the UMCP-1/ urinary creatinine （Ucr） in group B increased significantly （P〈0.01 ）, and increased further in group C and group D （P 〈 0.01 ）; UMCP-1/Ucr was positively related with ACR, HbAlc, serum TC and TG. Conclusions UMCP-1 excretion is increased in type 2 diabetics, which is related to the degree of dia- betic nephropathy.