Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants |
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| Authors: | Wellcome Trust Case Control Consortium;Australo-Anglo-American Spondylitis Consortium Burton Paul R Clayton David G Cardon Lon R Craddock Nick Deloukas Panos Duncanson Audrey Kwiatkowski Dominic P McCarthy Mark I Ouwehand Willem H Samani Nilesh J Todd John A Donnelly Peter Barrett Jeffrey C Davison Dan Easton Doug Evans David M Leung Hin-Tak Marchini Jonathan L Morris Andrew P Spencer Chris C A Tobin Martin D Attwood Antony P Boorman James P Cant Barbara Everson Ursula Hussey Judith M Jolley Jennifer D Knight Alexandra S Koch Kerstin Meech Elizabeth Nutland Sarah Prowse Christopher V |
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| Affiliation: | Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK. |
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| Abstract: | We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. |
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