离子液体在放射性核素标记中的应用

离子液体是一类新的绿色化学溶剂，在诸多领域有着广阔的应用前景。目前已经有学者将离子液体应用于放射性核素标记领域。本文综述了几种重要放射性核素或其稳定同位素在离子液体中的标记研究。在¹⁸F、¹²⁵I标记中，使用离子液体可以促进标记反应的进行，简化标记反应流程，缩短反应时间，并减少副产物的产生。此外，由于离子液体对金属离子的溶解度高、有着较好缓冲能力等优势，离子液体也被应用于⁹⁹Tc^m、⁶⁸Ga的标记研究。作为一个新的应用方向，离子液体在放射性核素标记中的应用可能会为放射性药物的发展提供新的动力。

Application of Ionic Liquids in Radionuclide Labelling

Ionic liquids are novel green chemical solvents with broad application prospects in many fields.At present,ionic liquids have been applied in the field of radionuclide labelling.In the article,the applications of ionic liquids in labeling of several important radionuclides or their stable isotopes are introduced.In ¹⁸F and ¹²⁵I labelling,the use of ionic liquids can promote the progress of the reaction,simplify the process of labelling,shorten the time,and reduce the amounts of by-products.In addition,the ionic liquids are also applied in the labelling of ⁹⁹Tc_m,and ⁶⁸Ga because of the high solubility of ionic liquids for metal ions and good buffering capacity.As a new application direction,the application of ionic liquids in radionuclide labelling may prompt the development of radiopharmaceuticals.