| 柔毛淫羊藿对骨质疏松小鼠的作用研究 |
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| 引用本文： | 韩小东,张金娟,任光友,张贵林.柔毛淫羊藿对骨质疏松小鼠的作用研究[J].中国医药导报,2011,8(19):55-56. |
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| 作者姓名： | 韩小东 张金娟 任光友 张贵林 |
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| 作者单位： | 1. 延安大学医学院临床系,陕西延安,716000
2. 贵阳医学院药理教研室,贵州贵阳,550004 |
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| 摘 要： | 目的：探讨柔毛淫羊藿对骨质疏松小鼠骨密度、破骨细胞和IL-6的作用。方法：采用切除雌性小鼠双侧卵巢复制骨质疏松整体动物模型,按小鼠体重随机分对照组（蒸馏水10 ml/kg）、模型组（蒸馏水10 ml/kg）、DES组（2 mg/kg）、EPM高剂量组（200 mg/kg）、EPM中剂量组（100 mg/kg）、EPM低剂量组（50 mg/kg）,每组14只。无钙饲料喂养,自然饮水。分别按各组相应药物相应剂量灌胃给药,60 d后测小鼠骨密度、破骨细胞数和IL-6含量。结果：模型组动物呈现明显的骨质疏松表现;给药组动物骨密度增加、破骨细胞数和IL-6表达明显降低,且有统计学意义。结论：柔毛淫羊藿能够增加去卵巢骨质疏松症小鼠的骨密度、降低破骨细胞数和IL-6的表达。
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| 关 键 词： | 柔毛淫羊藿 骨质疏松 IL-6 骨密度 |
Effects of Epimedium pubescens Maxim.on osteoporosis in ovariectomized mouse |
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| HAN Xiaodong,ZHANG Jinjuan,REN Guangyou,ZHANG Guilin.Effects of Epimedium pubescens Maxim.on osteoporosis in ovariectomized mouse[J].China Medical Herald,2011,8(19):55-56. |
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| Authors: | HAN Xiaodong ZHANG Jinjuan REN Guangyou ZHANG Guilin |
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| Affiliation: | 1.Clinical Medicine,Yan′an University Medical College,Shaanxi 716000,China;2.Department of Pharmacology,Guiyang Medical College,Guizhou 550004,China |
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| Abstract: | Objective:To explore the effect of EPM on osteoporosis in ovariectomized mouse.Methods:An ovariectomized mouse model was established.These mice were divided into six groups:control group,model group,diethylstilbestrol positive control group,high dose of EPM group,middle dose of EPM group and low dose of EPM group.Each group of 14.60 days after,bone density,the osteoclast and IL-6 of the bone tissue was measured.Results:The model group animals had the obvious performance of osteoporosis;bone density increase... |
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| Keywords: | IL-6 |
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