| 新型锍类化合物的合成及其DNA复合性能 |
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| 引用本文： | 吴春阳,吴晨悦,张莹,余丽芸,李婧.新型锍类化合物的合成及其DNA复合性能[J].合成化学,2017(1). |
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| 作者姓名： | 吴春阳 吴晨悦 张莹 余丽芸 李婧 |
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| 作者单位： | 黑龙江八一农垦大学 生命科学技术学院,黑龙江 大庆,163319 |
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| 基金项目： | 国家自然科学基金资助项目，黑龙江八一农垦大学大学生创新创业训练计划项目 |
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| 摘 要： | 报道了一类新型的以锍离子提供正电荷的阳离子脂质体的合成。以四氢噻吩和四氢噻喃为原料,在四氟硼酸银体系中与链状碘代脂肪烷烃经取代反应制得硫正离子化合物,产物用氯离子交换树脂交换得阴离子为氯离子的8种新型的链状锍类鎓氯盐脂质体化合物,其结构经~1H NMR,~(13)C NMR,FT-IR和HR-MS(ESI)表征。凝胶电泳阻滞实验表明该类锍化合物具有和DNA聚合并形成复合物的能力,随着脂肪链的增长,复合能力增强。
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| 关 键 词： | 四氢噻吩 四氢噻喃 碘代烷 锍类化合物 阳离子脂质体 DNA复合物 合成 DNA复合性能 |
Synthesis and DNA Condensing Properties of Novel Sulfonium Compounds |
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| WU Chun-yang,WU Chen-yue,ZHANG Ying,YU Li-yun,LI Jing?.Synthesis and DNA Condensing Properties of Novel Sulfonium Compounds[J].Chinese Journal of Synthetic Chemistry,2017(1). |
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| Authors: | WU Chun-yang WU Chen-yue ZHANG Ying YU Li-yun LI Jing? |
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| Abstract: | A new type of cationic lipid composed with sulfonium as the positive charge was reported. The sulfonium compounds were synthesized starting from tetrahedrothiophene and tetrahedrothiopyran by reaction with lipid iodides in the presence of silver tetrafluoro borate. The products were treated with chloro type anion exchange resin to give eight novel sulfonium chloride compounds. The structures were characterized by 1 H NMR, 13 C NMR, FT-IR and HR-MS( ESI) . Gel retardation experiments showed that the sulfonium compounds can condense DNA and form the lipopolyplex effectively. The results re-vealed that compound with longer lipid chain have stronger condensing effect. |
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| Keywords: | tetrahedrothiophene tetrahedrothiopyran lipid iodide sulfonium compound cationic lip-id DNA complex synthesis DNA condensing property |
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